Acute hepatic failure associated with oral minocycline: a case report.

abstract：:Clinical outcomes that measure how patients feel, function, or survive are the most important and relevant outcomes of therapy in clinical trials and in clinical practice. Surrogate end points, which do not directly measure clinical benefit to the patient, may function as substitutes for clinical end points in clinica...

journal_title：Pharmacotherapy

authors： Powers JH

更新日期：2005-12-01 00:00:00

abstract：STUDY OBJECTIVE:To determine if milk thistle (silymarin) alters the pharmacokinetics of indinavir. DESIGN:Sequential crossover trial. SETTING:General clinical research center. SUBJECTS:Ten healthy subjects. INTERVENTION:Indinavir 800 mg 3 times/day was given for four doses on days 1 and 2. Silymarin 160 mg 3 times/...

journal_title：Pharmacotherapy

authors： DiCenzo R,Shelton M,Jordan K,Koval C,Forrest A,Reichman R,Morse G

更新日期：2003-07-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effects of mild-to-moderate induced hypothermia-a neuroprotectant and/or therapeutic strategy for the management of intracranial hypertension in neurologically injured patients-on the pharmacokinetics of aminoglycoside therapy. DESIGN:Pharmacokinetic analysis. SETTING:Critical care un...

journal_title：Pharmacotherapy

authors： Mercer JM,Neyens RR

更新日期：2010-07-01 00:00:00

abstract：:The atypical antipsychotic agents clozapine and risperidone bring new insight into the care and treatment of patients with schizophrenia. Since their introduction, several names (e.g., novel, atypical, serotonergic-dopaminergic antagonist) have been used to describe the nature of these compounds. The agents are unique...

journal_title：Pharmacotherapy

authors： Raleigh F

更新日期：1996-11-01 00:00:00

abstract：:Endothelin (ET)-1 is an endothelium-derived peptide with potent vasoconstrictor and proliferative properties. The ET system is activated in several cardiovascular disease states associated with functional and structural vascular changes, including hypertension and heart failure. The two ET receptor subtypes are known ...

journal_title：Pharmacotherapy

authors： Ergul A

更新日期：2002-01-01 00:00:00

abstract：:In October 2009, a 2-day, multistakeholder, national conference was held in Rockville, Maryland, to discuss and propose methods to improve the drug-drug interaction (DDI) evidence base and its evaluation and integration into clinical decision support (CDS) systems. The conference featured participants representing con...

journal_title：Pharmacotherapy

authors： Hines LE,Malone DC,Murphy JE

更新日期：2012-04-01 00:00:00

abstract：STUDY OBJECTIVES:To compare the cost-effectiveness of intravenous plus oral amiodarone, atrial septal pacing, and both strategies combined to prevent atrial fibrillation after open heart surgery. Secondary objectives were to compare the cost-effectiveness of amiodarone versus no amiodarone and of pacing versus no pacin...

journal_title：Pharmacotherapy

authors： Reddy P,Kalus JS,Caron MF,Horowitz S,Karapanos A,Coleman CI,Kluger J,White CM

更新日期：2004-08-01 00:00:00

abstract：:The authors sought to evaluate the impact on length of hospital stay and treatment duration of morphine after implementation of a change in the institutional protocol for managing neonatal abstinence syndrome (NAS) in an effort to improve patient outcomes. A single-center, retrospective chart review was conducted at a...

journal_title：Pharmacotherapy

authors： DeAtley HN,Burton A,Fraley MD,Haltom J

更新日期：2017-07-01 00:00:00

abstract：:The risk of venous thromboembolism (VTE) in patients with cancer is 6-12-fold higher than in the general population, and VTE is the second leading cause of death in this population, after cancer itself. The etiology underlying the increased risk of VTE is multifactorial and complex, involving patient-, tumor-, and tre...

journal_title：Pharmacotherapy

authors： Saraiya B,Goodin S

更新日期：2009-11-01 00:00:00

abstract：:Hormonal emergency contraceptives have been used to prevent unwanted pregnancy for more than 3 decades. The mechanisms of action of the regimen containing a combination of estrogen and progestin, known as the Yuzpe regimen, and those of the levonorgestrel regimen continue to be controversial, especially over the possi...

journal_title：Pharmacotherapy

authors： Leung VW,Levine M,Soon JA

更新日期：2010-02-01 00:00:00

abstract：:Warfarin is an anticoagulant available as a racemic mixture. The R- and S-isomers differ with respect to relative plasma concentrations, clearance, potency, sites of metabolism, and cytochrome P450 (CYP) isoenzymes responsible for metabolism. S-Warfarin, the more potent isomer, is metabolized primarily by CYP2C9. Gene...

journal_title：Pharmacotherapy

authors： Redman AR

更新日期：2001-02-01 00:00:00

abstract：:A 43-year-old man with a 19-year history of Crohn's disease experienced serum sickness with acute lobular panniculitis and vasculitis within 2 weeks of initiating 6-mercaptopurine therapy. He had no history of extraintestinal manifestations of Crohn's disease or drug allergy. Symptoms included disabling joint pain, pr...

journal_title：Pharmacotherapy

authors： Andersen JM,Tiede JJ

更新日期：1997-01-01 00:00:00

abstract：STUDY OBJECTIVES:To develop and validate a self-assessment adherence tool for imatinib in patients with chronic myeloid leukemia (CML), and to correlate the use of this tool with response to treatment and adverse effects. DESIGN:Retrospective cohort study. SETTING:Regional cancer center in France. PATIENTS:Forty-six...

journal_title：Pharmacotherapy

authors： Daouphars M,Ouvry M,Lenain P,Rouvet J,Jardin F,Bubenheim M,Varin R

更新日期：2013-02-01 00:00:00

abstract：:Midazolam is a commonly used sedative in critically ill, mechanically ventilated patients in intensive care unit (ICU) settings worldwide. We used a nine-step decision-making algorithm to determine whether therapeutic monitoring of midazolam in the ICU is warranted. Midazolam has a higher clearance and shorter half-li...

journal_title：Pharmacotherapy

authors： Spina SP,Ensom MH

更新日期：2007-03-01 00:00:00

abstract：:We have developed a method for measuring the efficacy of a single dose of an analgesic for 12 hours after administration to outpatients with postoperative oral surgery pain. Using a self-rating record, patients evaluate their pain and its relief for 12 hours after medication. We have used this method successfully in a...

journal_title：Pharmacotherapy

authors： Beaver WT,Forbes JA,Shackleford RW

更新日期：1983-03-01 00:00:00

abstract：:Graves' disease is an autoimmune process in which the thyroid gland is stimulated by autoantibodies, leading to hyperthyroidism. Graves' disease is the most common cause of hyperthyroid function, primarily affecting women in their 40s and 50s. Treatment may involve oral radioiodine, which is taken up by the follicular...

journal_title：Pharmacotherapy

authors： Kolade VO,Bosinski TJ,Ruffy EL

更新日期：2005-07-01 00:00:00

abstract：:The clinical significance of rifampin's induction of warfarin metabolism is well documented, but no published studies or case reports have quantified this interaction with respect to the international normalized ratio (INR). A patient receiving concomitant rifampin and warfarin to treat a mycobacterial infection and i...

journal_title：Pharmacotherapy

authors： Lee CR,Thrasher KA

更新日期：2001-10-01 00:00:00

abstract：:Severe thermal injury is associated with hypermetabolism and hypercatabolism, leading to skeletal muscle breakdown, lean body mass loss, weight loss, and negative nitrogen balance. Muscle protein catabolism in patients with severe thermal injury is the result of stress-induced increased release of cytokines and counte...

journal_title：Pharmacotherapy

authors： Miller JT,Btaiche IF

更新日期：2009-02-01 00:00:00

abstract：:Resistance of nosocomial and community-acquired pathogens to antimicrobial agents is a serious problem with significant clinical consequences. Microbiologic surveillance data, such as those provided by the National Nosocomial Infections Surveillance System, supply information on current nosocomial pathogens in the Uni...

journal_title：Pharmacotherapy

authors： Thornsberry C

更新日期：1995-01-01 00:00:00

abstract：:Among various forms of hearing loss, there are acute (within 72 hrs) or subacute (weeks to months) presentations that may be reversible with early pharmacological intervention. The workup of a patient presenting with hypoacusia includes the usual history and physical examination in conjunction with an audiometric asse...

journal_title：Pharmacotherapy

authors： Fazel MT,Jedlowski PM,Cravens RB Jr,Erstad BL

更新日期：2017-12-01 00:00:00

abstract：:Postoperative atrial fibrillation (POAF) is the most common complication following cardiac surgery, occurring in up to 65% of cardiac surgical patients. It is a condition associated with increased morbidity, increased length of hospital stay, and increased health care costs. One of the many potential causes of POAF is...

journal_title：Pharmacotherapy

authors： Worden JC,Asare K

更新日期：2014-11-01 00:00:00

abstract：:Torsades de pointes is a polymorphic ventricular tachycardia characterized by marked QT prolongation on the electrocardiogram. It can be induced by both antiarrhythmic and nonantiarrhythmic drugs, such as quinidine and erythromycin. No extensive literature documents an interaction between quinidine and erythromycin wh...

journal_title：Pharmacotherapy

authors： Lin JC,Quasny HA

更新日期：1997-05-01 00:00:00

abstract：:Two drugs commonly used in triple-drug therapy for treatment of a Helicobacter pylori infection, clarithromycin and omeprazole, have rarely been associated with hypoglycemia when given alone. No documented interactions between H. pylori treatment with clarithromycin, amoxicillin, and omeprazole and insulin detemir hav...

journal_title：Pharmacotherapy

authors： Otsuka SH

更新日期：2013-04-01 00:00:00

abstract：:Colistin, the most widely used polymyxin antibiotic, was originally introduced in the late 1950s before the establishment of the present-day drug approval process. Originally shelved due to toxicity concerns, colistin, in the form of its inactive prodrug colistin methanesulfonate, has undergone a renaissance in the pa...

journal_title：Pharmacotherapy

authors： Ortwine JK,Kaye KS,Li J,Pogue JM

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To compare the effectiveness of an evidence-based, systematic approach to hypertension care involving comanagement of patients by primary care physicians and clinical pharmacists versus usual care in reducing blood pressure in patients with uncontrolled hypertension. METHODS:Patients in a staff model medical...

journal_title：Pharmacotherapy

authors： Borenstein JE,Graber G,Saltiel E,Wallace J,Ryu S,Archi J,Deutsch S,Weingarten SR

更新日期：2003-02-01 00:00:00

abstract：:Major depression afflicts a significant percentage of the population, and optimum therapy is often limited by the poor tolerability and lethality in overdose of the tricyclic antidepressants. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine, sertraline, and, more recently, paroxetine are viewed as welcom...

journal_title：Pharmacotherapy

authors： Nemeroff CB

更新日期：1994-03-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the clinical course and long-term impact of high-dose acyclovir (HD-A, 800 mg 4 times/day) cytomegalovirus (CMV) prophylaxis failure in a CMV-seropositive abdominal solid organ transplant population. DESIGN:Retrospective cohort study. SETTING:Tertiary academic medical center. PATIENTS:A t...

journal_title：Pharmacotherapy

authors： Siodlak M,Jorgenson MR,Descourouez JL,Leverson GE,Mandelbrot DA,Smith JA,Redfield RR

更新日期：2018-07-01 00:00:00

abstract：:We compared total costs and adherence to the regimen of older versus newer angiotensin-converting enzyme (ACE) inhibitors for the treatment of elderly patients with hypertension. A computer search using the data base of a health care insurer identified 6176 subjects age 65 years or older who had ICD-9 coding for hyper...

journal_title：Pharmacotherapy

authors： Small RE,Freeman-Arnold SB,Goode JV,Pyles MA

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVES:To identify the impact of penicillin versus alternative β-lactams on clinical outcomes in patients with penicillin-susceptible Staphylococcus aureus (PSSA) bacteremia. DESIGN:Retrospective cohort study. SETTING:Academic medical center. PATIENTS:Adult patients with PSSA bacteremia treated with a β-lactam a...

journal_title：Pharmacotherapy

authors： Shah MD,Wardlow LC,Stevenson KB,Coe KE,Reed EE

更新日期：2018-07-01 00:00:00

abstract：:Advances in the care of critically ill patients and in diagnostic techniques, such as fiberoptic endoscopy, have enabled greater recognition of stress-related mucosal damage (SRMD). This condition is distinguished from chronic peptic ulcer disease by its greater number of lesions, proximal location in the acid-produci...

journal_title：Pharmacotherapy

authors： Peura DA

更新日期：1987-01-01 00:00:00