Identification of a gemcitabine-warfarin interaction.

abstract：BACKGROUND:Opioid prescribing by dentists for older patients receiving medications with potential contraindications and the subsequent impact on acute care outcomes is not well described. OBJECTIVES:Our objective of this paper was to evaluate the use of potentially inappropriate medication combinations (PIMCs) involvi...

journal_title：Pharmacotherapy

authors： Zhou J,Calip GS,Rowan S,McGregor JC,Perez RI,Evans CT,Gellad WF,Suda KJ

更新日期：2020-10-01 00:00:00

abstract：:A 58-year-old man experienced an asthma exacerbation after administration of nicotine nasal spray for smoking cessation. His medical history was significant for asthma, chronic obstructive pulmonary disease, hypertension, and tobacco use when he was prescribed nicotine nasal spray for smoking cessation in an outpatien...

journal_title：Pharmacotherapy

authors： Roth MT,Westman EC

更新日期：2002-06-01 00:00:00

abstract：STUDY OBJECTIVE:To investigate the adverse drug reactions (ADRs) from peginterferon alfa-2b plus ribavirin in patients infected with the hepatitis C virus (HCV). DESIGN:Prospective, observational, pharmacovigilance study. SETTING:Gastroenterology department of a French university hospital. PATIENTS:A cohort of conse...

journal_title：Pharmacotherapy

authors： Bagheri H,Fouladi A,Barange K,Lapeyre-Mestre M,Payen JL,Montastruc JL,Vinel JP

更新日期：2004-11-01 00:00:00

abstract：:A popular garlic preparation containing 1.3% allicin at a large dose (2400 mg) was evaluated in this open-label study in nine patients with rather severe hypertension (diastolic blood pressure > or = 115 mm Hg). Sitting blood pressure fell 7/16 (+/- 3/2 SD) mm Hg at peak effect approximately 5 hours after the dose, wi...

journal_title：Pharmacotherapy

authors： McMahon FG,Vargas R

更新日期：1993-07-01 00:00:00

abstract：:Death is the ultimate adverse drug event. Despite its importance, the frequency of fatal adverse drug events is unknown. Estimates in the United States are as high as 140,000/year, although this number is heavily disputed. Potential reasons and risks for fatal adverse drug events, as well as epidemiologic designs for ...

journal_title：Pharmacotherapy

authors： Kelly WN

更新日期：2001-05-01 00:00:00

abstract：:The pharmacokinetic characteristics of levofloxacin, moxifloxacin, and gatifloxacin include excellent oral bioavailability (90-99%), extensive penetration into tissues and body fluids, and an elimination half-life (6-12 hrs) that allows for once-daily dosing in patients with normal renal function. Levofloxacin and gat...

journal_title：Pharmacotherapy

authors： Rodvold KA,Neuhauser M

更新日期：2001-10-01 00:00:00

abstract：:Surgical hemostasis may be achieved by using a number of physical, chemical, or biologic methods. One such method is with topical thrombin; however, one member of that class of drugs, bovine-derived thrombin, is associated with potentially serious consequences such as development of immune-mediated coagulopathy. This ...

journal_title：Pharmacotherapy

authors： Naoum JJ

更新日期：2009-07-01 00:00:00

abstract：:The U.S. population continues to experience an alarmingly high rate of unintended pregnancies that have an impact on individual families and society alike. Lack of effective contraception accounts for most unintended pregnancies, along with incorrect use of contraceptives. The most common reversible contraceptive meth...

journal_title：Pharmacotherapy

authors： Rafie S,McIntosh J,Shealy KM,Borgelt LM,Forinash A,Shrader SP,Koepf ER,McClendon KS,Griffin BL,Horlen C,Karaoui LR,Rowe EL,Lodise NM,Wigle PR

更新日期：2014-09-01 00:00:00

abstract：STUDY OBJECTIVE:To describe the population pharmacokinetics and pharmacodynamic target attainment of ampicillin in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing controlled hypothermia (CH). DESIGN:Prospective, open-label pharmacokinetic study. SETTING:A 189-bed, freestanding children's tertiary care ...

journal_title：Pharmacotherapy

authors： Cies JJ,Fugarolas KN,Moore WS 2nd,Mason RW,Menkiti OR

更新日期：2017-04-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the pharmacokinetic profile of palifermin after intravenous dosing with either a collapsed dose of 180 microg/kg/day for 1 day or a standard dose of 60 microg/kg/day for 3 days, before and after myeloablative chemoradiotherapy and peripheral blood progenitor cell (PBPC) transplantation. DESIG...

journal_title：Pharmacotherapy

authors： Zia-Amirhosseini P,Hurd DD,Salfi M,Cheah TC,Aycock J,Cesano A

更新日期：2007-10-01 00:00:00

abstract：:Children warrant access to care from clinical pharmacists trained in pediatrics. The American College of Clinical Pharmacy Pediatrics Practice and Research Network (ACCP Pediatrics PRN) released an opinion paper in 2005 with recommendations for improving the quality and quantity of pediatric pharmacy education in coll...

journal_title：Pharmacotherapy

authors： Bhatt-Mehta V,Buck ML,Chung AM,Farrington EA,Hagemann TM,Hoff DS,LaRochelle JM,Pettit RS,Phan H,Potts AL,Smith KP,Parrish RH 2nd

更新日期：2013-02-01 00:00:00

abstract：STUDY OBJECTIVES:To compare the cost-effectiveness of intravenous plus oral amiodarone, atrial septal pacing, and both strategies combined to prevent atrial fibrillation after open heart surgery. Secondary objectives were to compare the cost-effectiveness of amiodarone versus no amiodarone and of pacing versus no pacin...

journal_title：Pharmacotherapy

authors： Reddy P,Kalus JS,Caron MF,Horowitz S,Karapanos A,Coleman CI,Kluger J,White CM

更新日期：2004-08-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the usage patterns of the lipid-based amphotericin B formulations at our institution and to compare the observed nephrotoxicity and efficacy of these formulations. DESIGN:Prospective and retrospective observational study SETTING:Urban 350-bed teaching hospital. PATIENTS:Sixty-seven nonhe...

journal_title：Pharmacotherapy

authors： Cannon JP,Garey KW,Danziger LH

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:To review the current pharmacotherapy for idiopathic pulmonary arterial hypertension (IPAH). METHODS:A search of the primary literature was conducted by using MEDLINE, the National Institutes of Health medical research Web site (www.clinicaltrials.gov), and the United States Food and Drug Administration's Ce...

journal_title：Pharmacotherapy

authors： Hackman AM,Lackner TE

更新日期：2006-01-01 00:00:00

abstract：:A 53-year-old woman with an intraabdominal infection secondary to Candida albicans experienced hyperbilirubinemia after receiving amphotericin B in two different formulations--amphotericin B deoxycholate and amphotericin B lipid complex. Only a few case reports of amphotericin B-induced hyperbilirubinemia have been do...

journal_title：Pharmacotherapy

authors： Olin JL,Spooner LM

更新日期：2006-07-01 00:00:00

abstract：:Infections caused by yeasts and molds continue to be associated with high rates of morbidity and mortality in both immunocompromised and immunocompetent patients. Many antifungal drugs have been developed over the past 15 years to aid in the management of these infections. However, treatment is still not optimal, as t...

journal_title：Pharmacotherapy

authors： Mohr J,Johnson M,Cooper T,Lewis JS,Ostrosky-Zeichner L

更新日期：2008-05-01 00:00:00

abstract：STUDY OBJECTIVE:To determine if development of acneiform rash is a predictor of objective response rate with lapatinib. DESIGN:Subanalysis of data from a prospective, phase II study. SETTING:Academic breast care clinic. PATIENTS:Forty-nine treatment-naïve patients with human epidermal growth factor receptor-2 (HER2)...

journal_title：Pharmacotherapy

authors： Parma J,Pavlick A,Schiff R,Osborne CK,Chang JC,Rimawi M,Trivedi MV

更新日期：2013-10-01 00:00:00

abstract：:The management of heart failure is complex. Initiating and maintaining drug therapy in patients with heart failure can be challenging. Many factors influence the heart failure syndrome and are important to account for when evaluating these patients. Concomitant diseases such as ischemic heart disease and hypertension ...

journal_title：Pharmacotherapy

authors： Gattis WA

更新日期：2000-11-01 00:00:00

abstract：:Limitations of traditional anticoagulants have led to the need for structured services to provide anticoagulation monitoring. Anticoagulation management services have historically filled this role. Novel antithrombotic agents currently in development have the potential to improve on the limitations of vitamin K antago...

journal_title：Pharmacotherapy

authors： Nutescu EA,Spinler SA,Dager WE,Bussey HI

更新日期：2004-10-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the effects of food on the bioavailability of testosterone undecanoate, testosterone, and 5alpha-dihydrotestosterone (DHT) after administration of a new oral testosterone undecanoate formulation, Andriol Testocaps. DESIGN:Randomized, open-label, crossover study with a 1-week washout period. ...

journal_title：Pharmacotherapy

authors： Bagchus WM,Hust R,Maris F,Schnabel PG,Houwing NS

更新日期：2003-03-01 00:00:00

abstract：STUDY OBJECTIVE:To determine whether early administration of adjuvant β-lactam in combination with vancomycin (COMBO) affects clinical outcomes compared to standard vancomycin therapy alone (STAN) among patients with methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection. DESIGN:Retrospective, multic...

journal_title：Pharmacotherapy

authors： Casapao AM,Jacobs DM,Bowers DR,Beyda ND,Dilworth TJ,REACH-ID Study Group.

更新日期：2017-11-01 00:00:00

abstract：:This study documents a pharmacokinetic interaction between carbamazepine and cyclosporine (CsA) in pediatric renal transplant recipients. Noncompartmental steady-state CsA pharmacokinetics were determined in three pediatric renal transplant recipients who were receiving both CsA and carbamazepine as long-term therapy ...

journal_title：Pharmacotherapy

authors： Cooney GF,Mochon M,Kaiser B,Dunn SP,Goldsmith B

更新日期：1995-05-01 00:00:00

abstract：:Warfarin is considered a high-risk drug because of its narrow therapeutic window, variability in dose response, and multitude of drug and food interactions. Although travel advice is available for patients who are taking warfarin, it is geared toward patients who are traveling to developed countries and tends to be la...

journal_title：Pharmacotherapy

authors： Truong T,Armor BL

更新日期：2012-03-01 00:00:00

abstract：:Acute graft-versus-host disease (GVHD) remains the major obstacle for successful allogeneic bone marrow transplantation (BMT). The frequency of grade II or higher acute GVHD ranges from 30-50% in human leukocyte antigen (HLA)-matched sibling transplants and 50-80% in HLA-matched unrelated transplants. The mortality an...

journal_title：Pharmacotherapy

authors： Tse JC,Moore TB

更新日期：1998-09-01 00:00:00

abstract：:Epinephrine overdose induces many negative complications in adults because of its alpha- and beta-adrenoreceptor activity. However, complications in newborns or children are rarely described. A 4-day-old, 2004-g female newborn was inadvertently given epinephrine at 100 times the usual dose; she developed hypokalemia a...

journal_title：Pharmacotherapy

authors： Fang W,Chen JY,Fang Y,Huang JL

更新日期：2005-09-01 00:00:00

abstract：:Hypoactive sexual desire disorder (HSDD) affects nearly 1 in 10 women. Thus, it is essential for pharmacists and other health care providers to be comfortable when discussing a patient's sexual health to ensure appropriate triage so that the specific causes of HSDD can be identified and potential recommendations provi...

journal_title：Pharmacotherapy

authors： Lodise NM

更新日期：2013-04-01 00:00:00

abstract：:Ondansetron hydrochloride dihydrate is a 5-hydroxytryptamine (5-HT3) antagonist that was recently approved by the Food and Drug Administration for the treatment of chemotherapy-induced emesis. The mechanism of action is thought to be due to competitive inhibition of specific serotonin receptors in the central nervous ...

journal_title：Pharmacotherapy

authors： Burnette PK,Perkins J

更新日期：1992-01-01 00:00:00

abstract：:Methotrexate, administered for treatment of pediatric and adult malignancies, is a direct renal toxin, which can lead to renal dysfunction, decreased methotrexate clearance, elevated methotrexate concentrations, and systemic toxicity. Although plasma methotrexate concentrations have been shown to decline precipitously...

journal_title：Pharmacotherapy

authors： Vilay AM,Mueller BA,Haines H,Alten JA,Askenazi DJ

更新日期：2010-01-01 00:00:00

abstract：:Aneurysmal subarachnoid hemorrhage (SAH) accounts for a significant percentage of morbidity and mortality among patients admitted to neurosurgical centers throughout the world. Even for individuals surviving beyond the initial presentation and intervention for aneurysmal SAH, the occurrence of cerebral vasospasm has t...

journal_title：Pharmacotherapy

authors： Weant KA,Ramsey CN 3rd,Cook AM

更新日期：2010-04-01 00:00:00

abstract：:We examined whether low doses of phenytoin, which should be associated with few dose-related side effects, may increase the levels of high-density lipoprotein (HDL) cholesterol. Of 35 healthy adult men who consented to participate, 31 completed the study. They took no medications and consumed no alcohol during the stu...

journal_title：Pharmacotherapy

authors： McKenney JM,Petrizzi KS,Briggs GC,Wright JT Jr

更新日期：1992-01-01 00:00:00