Abstract:
BACKGROUND:Opioid prescribing by dentists for older patients receiving medications with potential contraindications and the subsequent impact on acute care outcomes is not well described. OBJECTIVES:Our objective of this paper was to evaluate the use of potentially inappropriate medication combinations (PIMCs) involving opioids prescribed by dentists according to the Beers Criteria and risks of 30-day emergency department (ED) visits and all-cause hospitalization among commercially insured dental patients ages 65 years and older. METHODS:We conducted a retrospective cohort study of 40,800 older dental patient visits in which opioids were prescribed between 2011 and 2015 using the IBM MarketScan databases. Data collection from dental, medical, and pharmacy claims included information on the concurrent use of PIMCs and outcomes of all-cause acute care utilization over the 30-day period after dental encounters. RESULTS:For the overall cohort, the median age was 69 years, and 45% were women. The prevalence of PIMCs per Beers Criteria was 10.4%. A total of 947 all-cause acute care events were observed in the 30 days post-dental visit. Patients with PIMCs involving opioids prescribed by dentists according to the Beers Criteria had higher rates of acute care use (3.3% vs 2.2%, p<0.001), which were associated with an increased risk of all-cause acute care utilization (adjusted risk ratio [RR] 1.23, 95% confidence interval [CI] 1.02-1.48). A dose-response relationship was seen with increasing oral morphine equivalents prescribed and increased acute care utilization (p<0.001). CONCLUSION:A significant proportion of older patients receiving opioids at dental visits use psychotropic medications that in combination should be avoided according to the American Geriatric Society Beers Criteria.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Zhou J,Calip GS,Rowan S,McGregor JC,Perez RI,Evans CT,Gellad WF,Suda KJdoi
10.1002/phar.2452subject
Has Abstractpub_date
2020-10-01 00:00:00pages
992-1001issue
10eissn
0277-0008issn
1875-9114journal_volume
40pub_type
杂志文章相关文献
PHARMACOTHERAPY文献大全abstract::Personalized medicine has been a mainstay and in practice in transplant pharmacotherapy since the advent of the field. Decisions pertaining to the diagnosis, selection, and monitoring of transplant pharmacotherapy are aimed toward the individual, the allograft, and the overall immunologic needs of the patient. Recent ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2484
更新日期:2020-11-06 00:00:00
abstract:STUDY OBJECTIVE:To describe the pharmacokinetic disposition of tobramycin in children undergoing stem cell transplantation (SCT) after intravenous administration either every 24 hours or every 8 hours, and to use this information to create initial dosing guidelines for administration every 24 hours in this patient popu...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1592/phco.24.6.564.34743
更新日期:2004-05-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the influence of withholding continuous enteral nutrition for 1 hour before and after warfarin administration compared with the coadministration of warfarin with continuous enteral nutrition on changes in international normalized ratios (INRs). DESIGN:Retrospective, crossover case series. SE...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.28.3.308
更新日期:2008-03-01 00:00:00
abstract::Patients with atrial fibrillation (AF) who suffer an acute ischemic stroke are at risk for both hemorrhagic transformation and recurrent ischemic stroke in the acute post-stroke period. Oral anticoagulants are recommended for secondary stroke prevention in patients with AF. The optimal time to initiate anticoagulant t...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2345
更新日期:2020-01-01 00:00:00
abstract::The clinical significance of rifampin's induction of warfarin metabolism is well documented, but no published studies or case reports have quantified this interaction with respect to the international normalized ratio (INR). A patient receiving concomitant rifampin and warfarin to treat a mycobacterial infection and i...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.21.15.1240.33897
更新日期:2001-10-01 00:00:00
abstract:STUDY OBJECTIVE:To contrast the characteristics of two groups of anabolic-androgenic steroid (AAS) users-those with versus those without AAS dependence. DESIGN:Subanalysis of data from the Anabolic 500, a cross-sectional survey. PARTICIPANTS:One hundred twelve male AAS-dependent users and 367 AAS-nondependent users w...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/j.1875-9114.2012.01123
更新日期:2012-10-01 00:00:00
abstract::Two analyses were conducted to compare the cost-effectiveness of different intravenous immunoglobulin (IGIV) formulations: IGIV purified by caprylate precipitation and chromatography (IGIV-C) and IGIV manufactured by an older solvent-detergent method (IGIV-S/D). The results indicated that IGIV-C is associated with cos...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.2005.25.11part2.94S
更新日期:2005-11-01 00:00:00
abstract::A 71-year-old Caucasian woman was admitted to the hospital with right-sided weakness and slurred speech. Glioblastoma multiforme was diagnosed, and resection of the tumor was performed. During the patient's hospitalization, blood and urine cultures were obtained after her temperature rose to 103.3 degrees F. Four bloo...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.1.161
更新日期:2007-01-01 00:00:00
abstract::An 87-year-old African-American man came to the internal medicine clinic for a routine anticoagulation management visit. He had no complaints. His medical history was significant for stage IV-A follicular non-Hodgkin's lymphoma, atrial fibrillation, and hypertension. His long-term drug therapy consisted of warfarin, f...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.4.583
更新日期:2006-04-01 00:00:00
abstract::The management of heart failure is complex. Initiating and maintaining drug therapy in patients with heart failure can be challenging. Many factors influence the heart failure syndrome and are important to account for when evaluating these patients. Concomitant diseases such as ischemic heart disease and hypertension ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.20.18.385s.34609
更新日期:2000-11-01 00:00:00
abstract::Females of childbearing age represent a large population of solid organ transplant recipients. With fertility commonly restored after transplantation, the possibility of pregnancy becomes a reality for many patients. Since the first published report of a successful pregnancy after solid organ transplantation in 1963, ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1800
更新日期:2016-09-01 00:00:00
abstract::We conducted an extensive literature review to evaluate the appropriate use, route, and dose of vitamin K to reverse excessive anticoagulation. Issues such as sample size, study design, different patient populations, and various study end points confounded results. Of 18 studies published, 8 enrolled 229 patients to e...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.19.18.1415.30896
更新日期:1999-12-01 00:00:00
abstract::High-performance capillary electrophoresis (HPCE) is a new separation technique that is applied in the pharmaceutical sciences. Separations by HPCE occur in a narrow-bore capillary under the influence of an applied electrical field. Components of the sample matrix are separated and migrate at different rates based on ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the level of agreement between one subjective definition of major bleeding (criteria A) and two objective definitions: the International Society on Thrombosis and Haemostasis ([ISTH] criteria B) and the Italian Study of Complications of Anticoagulant Therapy ([ISCOAT] criteria C). DESIGN:Retr...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.28.9.1098
更新日期:2008-09-01 00:00:00
abstract::Aneurysmal subarachnoid hemorrhage (SAH) accounts for a significant percentage of morbidity and mortality among patients admitted to neurosurgical centers throughout the world. Even for individuals surviving beyond the initial presentation and intervention for aneurysmal SAH, the occurrence of cerebral vasospasm has t...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.30.4.405
更新日期:2010-04-01 00:00:00
abstract::The pharmacokinetic characteristics of levofloxacin, moxifloxacin, and gatifloxacin include excellent oral bioavailability (90-99%), extensive penetration into tissues and body fluids, and an elimination half-life (6-12 hrs) that allows for once-daily dosing in patients with normal renal function. Levofloxacin and gat...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.21.16.233s.33992
更新日期:2001-10-01 00:00:00
abstract::Invasive fungal infections, especially candidiasis and aspergillosis, are a major cause of morbidity and mortality. Many controversies surround the management of these infections. A critical overview of the recent Infectious Diseases Society of America practice guidelines is provided, as are comments on both the conun...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.21.12.175s.34506
更新日期:2001-08-01 00:00:00
abstract::The National Kidney Foundation developed and oversees the Kidney Disease Outcomes Quality Initiative, a process that develops clinical practice guidelines in nephrology. Recent guidelines address the evaluation, classification, and stratification of chronic kidney disease (CKD). These guidelines provide, for the first...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.25.4.491.61034
更新日期:2005-04-01 00:00:00
abstract::Carbamazepine is a potent anticonvulsant agent with proven efficacy in the treatment of partial and tonic-clonic seizures. An epileptic child treated with therapeutic dosages of carbamazepine developed severe hepatitis and hepatic insufficiency. She had a positive response to withdrawal of the drug and administration ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.19.3.252.30918
更新日期:1999-02-01 00:00:00
abstract::The popularity of amiodarone has grown due to its effectiveness in converting arrhythmia and its formulation availability. Formulations of the drug also contain iodine; the iodine content is 75 mg in a 200-mg tablet of amiodarone and 18.7 mg/ml in the intravenous solution. Approximately 10% of the iodine content of or...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.25.3.429.61602
更新日期:2005-03-01 00:00:00
abstract::We evaluated the efficacy and tolerability of amphotericin B triglyceride emulsion in 16 patients with acquired immunodeficiency syndrome-related candidal esophagitis and cryptococcosis, compared with standard amphotericin B in 24 patients. Compared with the conventional formulation, the fat emulsion was administered ...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the effect of fluoxetine on the pharmacokinetics and cardiovascular safety of cisapride at steady state in healthy men. DESIGN:Open-label, three-phase, sequential study. SETTING:Clinical research center. SUBJECTS:Twelve healthy male volunteers. INTERVENTIONS:Each subject was treated acco...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.21.2.149.34109
更新日期:2001-02-01 00:00:00
abstract::Consensus guidelines recommend antimicrobial stewardship in all hospitals with the following goals in mind: appropriate and judicious use of antimicrobial agents leading to increased drug safety, reduced antimicrobial utilization, reduction in the development and selection of resistant organisms, cost containment, and...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/j.1875-9114.2012.01162.x
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:Twice/day dosing of insulin glargine has been used to treat hyperglycemia in clinical practice; however, data supporting its use in the critically ill population are lacking. This study was designed to evaluate the safety and efficacy of twice/day insulin glargine in critically ill patients. METHODS:A retros...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2373
更新日期:2020-03-01 00:00:00
abstract::A major factor in delivering patient care is documenting activities by pharmacists. This documentation is not only essential to sustain existing programs but necessary to justify future growth of resources. A computerized documentation system for clinical interventions and workload activities was developed in a 340-be...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::Status epilepticus (SE) has a high mortality rate and is one of the most common neurologic emergencies. Fast progression of this neurologic emergency and lack of response to traditional antiepileptic drugs (AEDs) in most cases has challenged clinicians to use new agents. This article evaluates the efficacy and safety ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2229
更新日期:2019-03-01 00:00:00
abstract::Opioid-related adverse drug events (ORADEs) can have a significant impact on patient recovery after surgery. This review investigates the impact of two ORADEs, respiratory depression and postoperative ileus (POI), on clinical and economic outcomes. Opioid-induced ventilatory impairment is a potentially serious ORADE t...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/j.1875-9114.2012.01178.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety and efficacy of alfuzosin treatment on rate and time of stone expulsion in patients with uncomplicated distal ureteral stones. PATIENTS AND METHODS:Prospective, randomized, open-label, controlled study. Patients > 18 years of age presenting to the outpatient urology clinic with uncompl...
journal_title:Pharmacotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1002/phar.1593
更新日期:2015-05-01 00:00:00
abstract::Cisplatin in combination with other cytotoxic agents is the backbone for a potential cure of testicular germ cell neoplasms and is a critical factor in the substantial activity observed in the treatment of small cell lung cancer, bladder cancer, and ovarian germ cell tumors. Resistance to cisplatin at the onset of tre...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
abstract::The effect of treatment for hepatitis C viral infection on hemoglobin A(1c) (A1C) levels is not well described in the literature. We describe a 59-year-old man with type 2 diabetes mellitus whose A1C level became falsely low when ribavirin and peginterferon alfa-2b therapy were started for treatment of hepatitis C. Af...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.29.1.121
更新日期:2009-01-01 00:00:00