Abstract:
STUDY OBJECTIVE:To determine if development of acneiform rash is a predictor of objective response rate with lapatinib. DESIGN:Subanalysis of data from a prospective, phase II study. SETTING:Academic breast care clinic. PATIENTS:Forty-nine treatment-naïve patients with human epidermal growth factor receptor-2 (HER2)-positive locally advanced breast cancer, who were treated with neoadjuvant lapatinib monotherapy for 6 weeks; 47 patients were included in the final analysis. MEASUREMENTS AND MAIN RESULTS:Of the 49 patients enrolled, 33 (67%) developed a rash of any type, and 26 (55%) had acneiform rash. Of the 26 evaluable patients with acneiform rash (55%), 19 (73%) responded to lapatinib and 7 (27%) did not. Of the 21 evaluable patients without acneiform rash, 11 (67%) responded to treatment and 7 (33%) did not. Thus, no association was found between the occurrence of acneiform rash and response to lapatinib monotherapy. CONCLUSION:This study does not support the development of the acneiform rash as a predictor of clinical efficacy of lapatinib in the treatment of breast cancer.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Parma J,Pavlick A,Schiff R,Osborne CK,Chang JC,Rimawi M,Trivedi MVdoi
10.1002/phar.1308subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1126-9issue
10eissn
0277-0008issn
1875-9114journal_volume
33pub_type
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