The biology of thrombin in acute coronary syndromes.

abstract：STUDY OBJECTIVE:To develop and evaluate a peer review group (PRG) meeting using feedback data on a patient level to improve the quality of drug therapy for prevention of recurrent myocardial infarction. DESIGN:Prospective follow-up study. DATA SOURCE:General practitioners' computerized patients records (intervention ...

journal_title：Pharmacotherapy

authors： van der Elst ME,Bouvy ML,de Blaey CJ,de Boer A

更新日期：2006-02-01 00:00:00

abstract：:Levodopa is one of the principal agents administered to treat patients with Parkinson's disease (PD). Several pharmacologic strategies can limit its side effects and enhance its activity. Although certain exceptions apply, dosage adjustments and drug changes should be instituted slowly. Levodopa is typically introduce...

journal_title：Pharmacotherapy

authors： Berchou RC

更新日期：2000-01-01 00:00:00

abstract：:The clinical significance of rifampin's induction of warfarin metabolism is well documented, but no published studies or case reports have quantified this interaction with respect to the international normalized ratio (INR). A patient receiving concomitant rifampin and warfarin to treat a mycobacterial infection and i...

journal_title：Pharmacotherapy

authors： Lee CR,Thrasher KA

更新日期：2001-10-01 00:00:00

abstract：:High-performance capillary electrophoresis (HPCE) is a new separation technique that is applied in the pharmaceutical sciences. Separations by HPCE occur in a narrow-bore capillary under the influence of an applied electrical field. Components of the sample matrix are separated and migrate at different rates based on ...

journal_title：Pharmacotherapy

authors： Brunner LJ,DiPiro JT,Feldman S

更新日期：1995-01-01 00:00:00

abstract：:A popular garlic preparation containing 1.3% allicin at a large dose (2400 mg) was evaluated in this open-label study in nine patients with rather severe hypertension (diastolic blood pressure > or = 115 mm Hg). Sitting blood pressure fell 7/16 (+/- 3/2 SD) mm Hg at peak effect approximately 5 hours after the dose, wi...

journal_title：Pharmacotherapy

authors： McMahon FG,Vargas R

更新日期：1993-07-01 00:00:00

abstract：:Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts. We describe a 35-year-old woman who developed severe thrombotic complications due to heparinization and unrecognized HDAs. She had r...

journal_title：Pharmacotherapy

authors： Bream-Rouwenhorst HR,Hobbs RA

更新日期：2008-11-01 00:00:00

abstract：STUDY OBJECTIVE:To describe the pharmacokinetic disposition of tobramycin in children undergoing stem cell transplantation (SCT) after intravenous administration either every 24 hours or every 8 hours, and to use this information to create initial dosing guidelines for administration every 24 hours in this patient popu...

journal_title：Pharmacotherapy

authors： Dupuis LL,Sung L,Taylor T,Abdolell M,Allen U,Doyle J,Taddio A

更新日期：2004-05-01 00:00:00

abstract：:Sepsis and acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) are associated with high mortality rates despite recent therapeutic advances. Both disease states involve uncontrolled host defense responses that lead to inflammation, endothelial damage, enhanced coagulation, diminished fibrinolysis and...

journal_title：Pharmacotherapy

authors： MacLaren R,Jung R

更新日期：2002-09-01 00:00:00

abstract：:Calcium channel blockers, nitrates, and beta blockers are the primary agents used for the treatment of angina. Calcium has a central role in excitation-contraction, action potential generation, and ischemic cell death. The three currently available calcium antagonists are nifedipine, verapamil, and diltiazem. Second-g...

journal_title：Pharmacotherapy

authors： Angaran D

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of telephone follow-up on the physical well-being dimension of health-related quality of life in patients with cancer. DESIGN:Randomized, controlled trial. SETTING:Public teaching hospital. PATIENTS:One hundred fifty patients with cancer who were discharged to home from the hospital....

journal_title：Pharmacotherapy

authors： Beney J,Devine EB,Chow V,Ignoffo RJ,Mitsunaga L,Shahkarami M,McMillan A,Bero LA

更新日期：2002-10-01 00:00:00

abstract：:Buspirone is the first of a new class of anxioselective agents, the azaspirodecanediones. It achieves peak serum concentrations within one hour and has a serum half-life of 2 to 5 hours. Animal studies have suggested antianxiety activity and the absence of abuse potential. Buspirone is both a dopamine agonist and anta...

journal_title：Pharmacotherapy

authors： Goldberg HL

更新日期：1984-11-01 00:00:00

abstract：:Stenotrophomonas maltophilia, Burkholderia cepacia complex, Elizabethkingia spp., Chryseobacterium spp., Achromobacter spp., and Alcaligenes spp. are less-common non-lactose-fermenting bacteria that have emerged as important opportunistic pathogens. Patients at the highest risk for these infections include the immunoc...

journal_title：Pharmacotherapy

authors： Spencer HK,Spitznogle SL,Borjan J,Aitken SL

更新日期：2020-09-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the pharmacodynamics of four intravenous antimicrobial regimens-ceftriaxone 1 g, gatifloxacin 400 mg, levofloxacin 500 mg, and levofloxacin 750 mg, each every 24 hours-against recent Streptococcus pneumoniae isolates. DESIGN:Pharmacodynamic analysis using Monte Carlo simulation. DATA SOURC...

journal_title：Pharmacotherapy

authors： Frei CR,Burgess DS

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:To compare changes in United States pharmacy practice faculty demographics from 1995-2001 and to discuss the implications for junior faculty development. METHODS:Demographic data were extracted from the American Association of Colleges of Pharmacy institutional research system for academic years 1995-1996 an...

journal_title：Pharmacotherapy

authors： Raehl CL

更新日期：2002-04-01 00:00:00

abstract：:A retrospective study evaluated the success of dosages of simvastatin lower than the 10-20 mg/day recommended by the manufacturer in patients with hypercholesterolemia. Records of 95 patients enrolled in a pharmacist-managed lipid clinic receiving stable dosages of simvastatin were reviewed. Data collected were demogr...

journal_title：Pharmacotherapy

authors： Rindone JP

更新日期：1999-04-01 00:00:00

abstract：:Apixaban, a direct factor Xa inhibitor, is a novel oral anticoagulant (NOAC) indicated for prevention of embolic events in patients with nonvalvular atrial fibrillation. The agent is associated with a lower risk of bleeding compared with vitamin K antagonists such as warfarin. Hemopericardium is a life-threatening ble...

journal_title：Pharmacotherapy

authors： Sigawy C,Apter S,Vine J,Grossman E

更新日期：2015-07-01 00:00:00

abstract：:Concerns about cross-allergenicity between sulfonamide antibiotics and nonantibiotic, sulfonamide-containing drugs persist and can complicate patients' drug therapy unnecessarily. No interaction between the human immune system and the sulfonamide functional group has been demonstrated. The immunologic determinant of t...

journal_title：Pharmacotherapy

authors： Brackett CC,Singh H,Block JH

更新日期：2004-07-01 00:00:00

abstract：:Infection due to Mycobacterium tuberculosis continues to plague humanity. In the United States, conditions have taken a decided turn for the worse, with an increasing frequency of infection and the spread of multiple-drug-resistant strains. A number of strategies are available to improve the management of this epidemi...

journal_title：Pharmacotherapy

authors： Peloquin CA

更新日期：1993-11-01 00:00:00

abstract：:After injecting the solution extracted from a Primatene Mist inhaler, a patient experienced epinephrine overdose that resulted in an acute myocardial infarction and acute renal failure. The exact amount of epinephrine injected was unknown, but was thought to be between 82.5 and 124 mg, more than 25 times higher than t...

journal_title：Pharmacotherapy

authors： Woodard ML,Brent LD

更新日期：1998-05-01 00:00:00

abstract：:A 26-year-old woman developed significant unilateral anterior cervical and supraclavicular lymphadenopathy 3 days after receiving her first dose (of a total of three doses) of human papilloma virus (HPV) vaccine. She had no history of lymphadenopathy after other previous immunizations, and had received no vaccines oth...

journal_title：Pharmacotherapy

authors： Studdiford J,Lamb K,Horvath K,Altshuler M,Stonehouse A

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:As one of the most accessible health care professionals, pharmacists are in an ideal position to provide tobacco-cessation and prevention services. Although there is growing interest in expanding the pharmacist's role in tobacco treatment, few published studies have assessed the efficacy or effectiveness of ...

journal_title：Pharmacotherapy

authors： Dent LA,Harris KJ,Noonan CW

更新日期：2007-07-01 00:00:00

abstract：:Telavancin is a once-daily lipoglycopeptide antibiotic structurally derived from vancomycin. It has broad-spectrum activity against gram-positive bacteria, including strains with reduced susceptibility to vancomycin. Telavancin's multifunctional mechanism of action, including inhibition of peptidoglycan synthesis and ...

journal_title：Pharmacotherapy

authors： Leonard SN,Rybak MJ

更新日期：2008-04-01 00:00:00

abstract：:Warfarin is a commonly used oral anticoagulant that is usually initiated after the definitive diagnosis of a certain thromboembolic disorder or disease. Warfarin therapy will usually be prescribed for 6-12 weeks or more, and some patients may continue therapy throughout life, depending on the type of thromboembolic di...

journal_title：Pharmacotherapy

authors： Yamreudeewong W,Johnson JV,Cassidy TG,Berg JT

更新日期：1996-11-01 00:00:00

abstract：:The popularity of amiodarone has grown due to its effectiveness in converting arrhythmia and its formulation availability. Formulations of the drug also contain iodine; the iodine content is 75 mg in a 200-mg tablet of amiodarone and 18.7 mg/ml in the intravenous solution. Approximately 10% of the iodine content of or...

journal_title：Pharmacotherapy

authors： Brouse SD,Phillips SM

更新日期：2005-03-01 00:00:00

abstract：:Triclosan is a synthetic biocide found in many household products, including antimicrobial hand soap. Levels of triclosan have been found throughout the environment and in human urine, blood, and even breast milk. Increasing levels of exposure to triclosan have led to concerns over the development of resistance to tri...

journal_title：Pharmacotherapy

authors： Giuliano CA,Rybak MJ

更新日期：2015-03-01 00:00:00

abstract：STUDY OBJECTIVES:To compare the effectiveness of bivalirudin and argatroban in achieving anticoagulation goals and to compare clinical outcomes assessing the safety and efficacy in patients with known or suspected heparin-induced thrombocytopenia (HIT). DESIGN:Single-center, retrospective analysis. SETTING:Large tert...

journal_title：Pharmacotherapy

authors： Skrupky LP,Smith JR,Deal EN,Arnold H,Hollands JM,Martinez EJ,Micek ST

更新日期：2010-12-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effects of acetaminophen, naproxen, and acetylsalicylic acid on the pharmacokinetics of the centrally acting analgesic tapentadol in healthy subjects. DESIGN:Two randomized, open-label, crossover, drug-drug interaction studies. SETTING:Clinical research facilities in the United States ...

journal_title：Pharmacotherapy

authors： Smit JW,Oh C,Rengelshausen J,Terlinden R,Ravenstijn PG,Wang SS,Upmalis D,Mangold B

更新日期：2010-01-01 00:00:00

abstract：:We sought to summarize and assess original evaluations of the economic impact of clinical pharmacy services published from 1996-2000, and to provide recommendations and methodologic considerations for future research. A systematic literature search was conducted to identify articles that were then blinded and randomly...

journal_title：Pharmacotherapy

authors： Schumock GT,Butler MG,Meek PD,Vermeulen LC,Arondekar BV,Bauman JL,2002 Task Force on Economic Evaluation of Clinical Pharmacy Services of the American College of Clinical Pharmacy.

更新日期：2003-01-01 00:00:00

abstract：:The pharmacokinetic disposition of numerous antimicrobial agents is altered in critically ill patients. Pharmacokinetics of trovafloxacin, a fluoroquinolone indicated specifically for severe, life-threatening infections in the intensive care unit, have not been well studied in this population. We characterized the pha...

journal_title：Pharmacotherapy

authors： Olsen KM,Rebuck JA,Weidenbach T,Fish DN

更新日期：2000-04-01 00:00:00

abstract：:A 76-year-old man developed akinetic mutism after 3 days of receiving low-dosage baclofen. Electroencephalography showed a diffusely slow background with intermittent generalized sharp wave discharges. The condition resolved after discontinuing baclofen. To our knowledge, this is the first reported case of baclofen-in...

journal_title：Pharmacotherapy

authors： Rubin DI,So EL

更新日期：1999-04-01 00:00:00