Abstract:
:Calcium channel blockers, nitrates, and beta blockers are the primary agents used for the treatment of angina. Calcium has a central role in excitation-contraction, action potential generation, and ischemic cell death. The three currently available calcium antagonists are nifedipine, verapamil, and diltiazem. Second-generation agents are in development, and a classification system of calcium channel blockers is used to place the currently available agents and those on the horizon in perspective. Nitrate pharmacology and pharmacodynamics are possibly related to nitrate tolerance; however, this is a matter of some controversy. The beta blockers are all equally effective in the treatment of angina; therefore, drug selection is based on ancillary properties.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Angaran Ddoi
10.1002/j.1875-9114.1987.tb04052.xsubject
Has Abstractpub_date
1987-01-01 00:00:00pages
62S-71Sissue
5 Pt 2eissn
0277-0008issn
1875-9114journal_volume
7pub_type
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