Benzocaine-induced methemoglobinemia during an outpatient procedure.

abstract：STUDY OBJECTIVE:To evaluate the success of an initial tobramycin dosing regimen to achieve target peak and trough concentrations in adult patients with pulmonary exacerbations of cystic fibrosis (CF). DESIGN:Retrospective single-center medical record review. SETTING:Large tertiary care academic medical center. PATIE...

journal_title：Pharmacotherapy

authors： Staubes BA,Metzger NL,Walker SD,Peasah SK

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:There is a high prevalence of HIV infection in Newark, New Jersey, with University Hospital admitting approximately 600 HIV-infected patients per year. Medication errors involving antiretroviral therapy (ART) could significantly affect treatment outcomes. The goal of this study was to evaluate the effectiven...

journal_title：Pharmacotherapy

authors： Zucker J,Mittal J,Jen SP,Cheng L,Cennimo D

更新日期：2016-03-01 00:00:00

abstract：:Human herpesvirus infections continue to be a concern in immunocompetent as well as immunocompromised hosts. They are often life threatening in the immunocompromised patient. In the healthy immunocompetent person the infections tend to be self-limited, although they can directly or indirectly cause periods of severe d...

journal_title：Pharmacotherapy

authors： Dudley MN

更新日期：1995-09-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effect of acarbose on glycemic control and glycemic variability, using a continuous glucose-monitoring system, in patients with type 2 diabetes mellitus who were not well controlled on metformin and vildagliptin therapy. DESIGN:Multicenter, randomized, double-blind, placebo-controlled s...

journal_title：Pharmacotherapy

authors： Derosa G,Franzetti I,Querci F,D'Angelo A,Maffioli P

更新日期：2015-11-01 00:00:00

abstract：:We cared for a 4-year-old patient who had undergone orthotopic liver transplantation and was placed on a ventilator for respiratory distress associated with Pneumocystis carinii pneumonia. The neuromuscular blocking agent pancuronium bromide 1.0-1.2 mg every hour as needed was used to facilitate artificial ventilation...

journal_title：Pharmacotherapy

authors： Haas JL,Shaefer MS,Miwa LJ,Wood RP,Shaw BW Jr

更新日期：1989-01-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the frequency of medication errors, as well as the severity of harm resulting from these errors, related to the prescription, transcription, preparation, and administration of parenteral nutrition formulations. DESIGN:Prospective, observational study. SETTING:471-bed, academic teaching ho...

journal_title：Pharmacotherapy

authors： Sacks GS,Rough S,Kudsk KA

更新日期：2009-08-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effect of Niaspan--a niacin preparation with both immediate- and extended-release characteristics--on lipid and glycemic control in patients with type 2 diabetes. DESIGN:Retrospective study SETTING:Private-practice endocrinology group. PATIENTS:Thirty-two patients (mean age 60 yrs; 7...

journal_title：Pharmacotherapy

authors： Kane MP,Hamilton RA,Addesse E,Busch RS,Bakst G

更新日期：2001-12-01 00:00:00

abstract：:Anemia is an undertreated but common complication of cancer and is associated with debilitating symptoms that impair the patient's ability to perform daily functions of life. Treatment with darbepoetin alfa, a novel erythropoiesis-stimulating protein, is appropriate for chemotherapy-induced anemia. Guidelines on darbe...

journal_title：Pharmacotherapy

authors： Bloomfield M,Jaresko G,Zarek J,Dozier N

更新日期：2003-12-01 00:00:00

abstract：:Oral anticoagulation with warfarin requires routine monitoring of prothrombin time, expressed as the international normalized ratio (INR). Patient self-testing for INR is common in Europe but not in the United States. In order to determine the frequency of INR self-testing among patients whose anticoagulant therapy is...

journal_title：Pharmacotherapy

authors： Wittkowsky AK,Sekreta CM,Nutescu EA,Ansell J

更新日期：2005-02-01 00:00:00

abstract：:A 58-year-old woman who had been taking digoxin 0.25 mg/day for more than 35 years for heart palpitations after mitral valve repair was prescribed a 5-day course of telithromycin for acute bronchitis. On the sixth day of therapy, she came to the emergency department complaining of general malaise and having experience...

journal_title：Pharmacotherapy

authors： Nenciu LM,Laberge P,Thirion DJ

更新日期：2006-06-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the hemodynamic and electrocardiographic effects of a single dose of commercially available bitter-orange dried-fruit extract, which is increasingly being used in dietary supplements. DESIGN:Randomized, double-blind, placebo-controlled, crossover study. SETTING:University of Connecticut, S...

journal_title：Pharmacotherapy

authors： Min B,Cios D,Kluger J,White CM

更新日期：2005-12-01 00:00:00

abstract：:We present a case of eosinophilic pneumonia due to ceftaroline used for the treatment of methicillin-resistant Staphylococcus aureus bacteremia associated with a postoperative spinal infection. Our patient developed shortness of breath and hypoxemia on the fifth week of ceftaroline therapy. Chest imaging disclosed dif...

journal_title：Pharmacotherapy

authors： Desai KR,Burdette SD,Polenakovik HM,Hagaman J,Pleiman CM

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety and efficacy of alfuzosin treatment on rate and time of stone expulsion in patients with uncomplicated distal ureteral stones. PATIENTS AND METHODS:Prospective, randomized, open-label, controlled study. Patients > 18 years of age presenting to the outpatient urology clinic with uncompl...

journal_title：Pharmacotherapy

authors： El Said NO,El Wakeel L,Kamal KM,Morad Ael R

更新日期：2015-05-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effect of a high-fat breakfast on single-dose, zidovudine (ZDV) pharmacokinetics. DESIGN:Open-label, randomized, crossover study. PATIENTS:Eighteen asymptomatic subjects (12 men, 6 women) infected with the human immunodeficiency virus (mean CD4 cell counts of 512 +/- 178/mm3). INTERV...

journal_title：Pharmacotherapy

authors： Shelton MJ,Portmore A,Blum MR,Sadler BM,Reichman RC,Morse GD

更新日期：1994-11-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the influence of withholding continuous enteral nutrition for 1 hour before and after warfarin administration compared with the coadministration of warfarin with continuous enteral nutrition on changes in international normalized ratios (INRs). DESIGN:Retrospective, crossover case series. SE...

journal_title：Pharmacotherapy

authors： Dickerson RN,Garmon WM,Kuhl DA,Minard G,Brown RO

更新日期：2008-03-01 00:00:00

abstract：:Recent attention has been called to the interpretation of studies of antiinfective agents demonstrating effects on the QTc interval. It seems that the effects of many of these agents on the QTc interval are small, but in some patient populations, these drugs may cause morbidity and mortality related to TdP. It would b...

journal_title：Pharmacotherapy

authors： Owens RC Jr,Ambrose PG

更新日期：2002-05-01 00:00:00

abstract：:Cardiotoxicity due to tacrolimus is documented infrequently in the medical literature. Sinus bradycardia associated with intravenous tacrolimus occurred in a 15-year-old orthotopic liver transplant recipient. The mechanism of this adverse effect is unknown; however, it does not appear to be concentration dependent, an...

journal_title：Pharmacotherapy

authors： Cox TH,Baillie GM,Baliga P

更新日期：1997-11-01 00:00:00

abstract：:Stroke is the third most common cause of death in the United States and is the number one cause of long-term disability. Legislative mandates, largely the result of the American Heart Association, American Stroke Association, and Brain Attack Coalition working cooperatively, have resulted in nationwide standardization...

journal_title：Pharmacotherapy

authors： Baldwin K,Orr S,Briand M,Piazza C,Veydt A,McCoy S

更新日期：2010-05-01 00:00:00

abstract：:Antimicrobial resistance among gram-positive organisms such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) continues to limit therapeutic options. The oxazolidinones are a synthetic class of agents now commonly relied on for the treatment of serious MRSA and VRE infect...

journal_title：Pharmacotherapy

authors： Rybak JM,Marx K,Martin CA

更新日期：2014-11-01 00:00:00

abstract：:Infection due to Mycobacterium tuberculosis continues to plague humanity. In the United States, conditions have taken a decided turn for the worse, with an increasing frequency of infection and the spread of multiple-drug-resistant strains. A number of strategies are available to improve the management of this epidemi...

journal_title：Pharmacotherapy

authors： Peloquin CA

更新日期：1993-11-01 00:00:00

abstract：:A 67-year-old woman with iron deficiency anemia required parenteral iron therapy and was treated with intravenous ferric gluconate. She tolerated the first dose, but after the second dose, she developed a tingling feeling all over her body, along with swelling in her hands and feet, and a rash with hives over most of ...

journal_title：Pharmacotherapy

authors： Sane R,Baribeault D,Rosenberg CL

更新日期：2007-04-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the safety, tolerability, and pharmacokinetic profile of fosphenytoin, a water-soluble phenytoin prodrug, after intramuscular and intravenous administration. DESIGN:Open-label study of intramuscular administration, and double-blind, randomized study of intravenous administration. SETTING:S...

journal_title：Pharmacotherapy

authors： Boucher BA,Feler CA,Dean JC,Michie DD,Tipton BK,Smith KR Jr,Kramer RE,Young B,Parks BR Jr,Kugler AR

更新日期：1996-07-01 00:00:00

abstract：:Clopidogrel decreases the morbidity and mortality associated with several cardiovascular diseases. However, clopidogrel is a prodrug that needs to be metabolized to the active thiol metabolite by the cytochrome P450 (CYP) system. This activation is a source of significant interindividual variability in clopidogrel res...

journal_title：Pharmacotherapy

authors： Momary KM,Dorsch MP,Bates ER

更新日期：2010-03-01 00:00:00

abstract：:We conducted a meta-analysis to determine what factors in treatment regimens for Helicobacter pylori are associated with increased discontinuation rates. Studies were selected from the 1990-1996 MEDLINE data base, and references in published articles and reviews were obtained. Each article was uniformally abstracted f...

journal_title：Pharmacotherapy

authors： Buring SM,Winner LH,Hatton RC,Doering PL

更新日期：1999-03-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the accuracy of four equations based on serum creatinine concentration-the original Schwartz equation and the Leger, Bedside Chronic Kidney Disease in Children (CKiD), and Counahan-Barratt equations-for determining glomerular filtration rate (GFR) in pediatric patients with chronic kidney di...

journal_title：Pharmacotherapy

authors： Lee CK,Swinford RD,Cerda RD,Portman RJ,Hwang W,Furth SL

更新日期：2012-07-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate the effectiveness of pharmacist-administered diabetes mellitus education and management services on selected diabetes performance measures. Additional goals were to compare outcomes with goals specified for patients with diabetes by the National Committee for Quality Assurance (NCQA) and id...

journal_title：Pharmacotherapy

authors： Ragucci KR,Fermo JD,Wessell AM,Chumney EC

更新日期：2005-12-01 00:00:00

abstract：:Aspirin has been used for the prevention and treatment of cardiovascular disease (CVD) for several decades. The efficacy of aspirin for secondary prevention of cardiovascular disease is well established, but the clinical benefit of aspirin for primary prevention of CVD is less clear. The primary literature suggests th...

journal_title：Pharmacotherapy

authors： Nemerovski CW,Salinitri FD,Morbitzer KA,Moser LR

更新日期：2012-11-01 00:00:00

abstract：STUDY OBJECTIVES:To identify subsequent therapies used after first-line therapies in patients with advanced non-small cell lung cancer (NSCLC), compare overall survival (OS) associated with subsequent therapies, and evaluate factors associated with OS in these patients. METHODS:The study was a retrospective cohort ana...

journal_title：Pharmacotherapy

authors： Afanasjeva J,Hui RL,Spence MM,Chang J,Schottinger JE,Millares M,Rashid N

更新日期：2016-10-01 00:00:00

abstract：:Struvite calculi result from urinary tract infections secondary to urease-producing bacteria. To prevent recurrent infection and stone formation complete removal of struvite calculi is recommended. Two illustrative reports of patients with renal struvite calculi are presented in which 10% hemiacidrin (Renacidin) irrig...

journal_title：Pharmacotherapy

authors： Massaro FJ,Weiner B,Sant GR,Meares EM Jr

更新日期：1983-11-01 00:00:00

abstract：:Warfarin is an anticoagulant available as a racemic mixture. The R- and S-isomers differ with respect to relative plasma concentrations, clearance, potency, sites of metabolism, and cytochrome P450 (CYP) isoenzymes responsible for metabolism. S-Warfarin, the more potent isomer, is metabolized primarily by CYP2C9. Gene...

journal_title：Pharmacotherapy

authors： Redman AR

更新日期：2001-02-01 00:00:00