Abstract:
:Apixaban, a direct factor Xa inhibitor, is a novel oral anticoagulant (NOAC) indicated for prevention of embolic events in patients with nonvalvular atrial fibrillation. The agent is associated with a lower risk of bleeding compared with vitamin K antagonists such as warfarin. Hemopericardium is a life-threatening bleeding event that is rarely caused by anticoagulants. We describe the case of a 76-year-old woman who was diagnosed with nonvalvular atrial fibrillation and treated with apixaban. Six weeks later, she was hospitalized after complaints of weakness and dizziness, and a chest radiograph revealed cardiomegaly. Further imaging, including a computed tomography scan and transthoracic echocardiogram, confirmed a diagnosis of hemopericardium. To our knowledge, this is the first case report of hemopericardium associated with apixaban therapy. This report, along with two previous cases reports of hemopericardium associated with dabigatran and rivaroxaban, emphasizes the need for careful use of NOACs and for further research to identify an antidote or other method for controlling hemorrhage secondary to NOACs in an acute setting. Furthermore, clinicians should consider hemopericardium in the differential diagnosis of patients treated with anticoagulants, including NOACs, who present with cardiomegaly.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Sigawy C,Apter S,Vine J,Grossman Edoi
10.1002/phar.1602subject
Has Abstractpub_date
2015-07-01 00:00:00pages
e115-7issue
7eissn
0277-0008issn
1875-9114journal_volume
35pub_type
杂志文章相关文献
PHARMACOTHERAPY文献大全abstract::The field of acid suppression has been advanced by therapeutics of increasing specificity for inhibiting gastric acid secretion. Particularly important are proton pump inhibitors (PPIs), which inhibit the activity of the gastric acid pump (H+,K(+)-adenosine triphosphatase), the final common step in gastric acid produc...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.23.13.68s.31931
更新日期:2003-10-01 00:00:00
abstract::The systemic polymyxins, colistin and polymyxin B, are increasingly used for multidrug-resistant bacterial infections and have a long history of dose-limiting toxicity. This review summarizes the most recent available information about the mechanisms, incidence, risk factors, and minimization strategies for polymyxin ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1493
更新日期:2015-01-01 00:00:00
abstract::In patients infected with chronic hepatitis B virus (HBV) that goes untreated, therapeutic options are limited once the disease decompensates, and orthotopic liver transplantation is often the only treatment available to save the patient's life. After liver transplantation, combined therapy with hepatitis B immune glo...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1306
更新日期:2013-09-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate the safety and efficacy of aerosolized ceftazidime for prevention of ventilator-associated pneumonia (VAP) and to evaluate the effects of the drug on the proinflammatory response. DESIGN:Prospective, randomized, double-blind, placebo-controlled clinical trial. SETTING:University teaching ...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1592/phco.22.12.972.33596
更新日期:2002-08-01 00:00:00
abstract:STUDY OBJECTIVES:To examine glycosylated hemoglobin (A1C) values longitudinally in patients who newly started metformin, sulfonylurea, or thiazolidinedione monotherapy; in a subset of patients whose A1C values were 7% or greater before starting therapy (baseline) and who achieved A1C goal (A1C < 7%) during therapy, rat...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.8.1102
更新日期:2007-08-01 00:00:00
abstract::Granulocyte-macrophage colony-stimulating factor (GMCSF) is a hematopoietic protein that has been studied both in vitro and in vivo in human immunodeficiency virus (HIV) infection. Since both HIV infection primarily and zidovudine (formerly AZT) treatment secondarily may result in neutropenia, administration of GMCSF ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1992-01-01 00:00:00
abstract::The clinical and economic impacts of bacterial resistance are substantial. The development of bacterial resistance during a course of therapy often leads to clinical failure, prolonged hospitalization, increased morbidity, mortality, and increased health care costs. Resistance has been reported to occur most frequentl...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1992-01-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the level of agreement between two sets of criteria, the Thrombolysis in Myocardial Infarction (TIMI) criteria and investigator-developed criteria, for identifying bleeding events in patients who had undergone a percutaneous coronary intervention (PCI) and to measure length of hospital stay ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.1.36
更新日期:2007-01-01 00:00:00
abstract::Gram-negative septicemia due to central venous catheter-related infection is a leading cause of mortality and morbidity among patients who undergo hemodialysis. Antibiotic-heparin locks are valuable for preserving access sites and lowering the cost and inconvenience associated with central venous catheter replacement ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.22.1.105.33507
更新日期:2002-01-01 00:00:00
abstract::Warfarin is an anticoagulant available as a racemic mixture. The R- and S-isomers differ with respect to relative plasma concentrations, clearance, potency, sites of metabolism, and cytochrome P450 (CYP) isoenzymes responsible for metabolism. S-Warfarin, the more potent isomer, is metabolized primarily by CYP2C9. Gene...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.21.2.235.34106
更新日期:2001-02-01 00:00:00
abstract::Methotrexate, a folic acid antagonist, is being employed more frequently in an attempt to control rheumatoid arthritis that has not responded adequately to conventional therapies. Systemic administration of 7.5-15 mg weekly in a pulse fashion appears to be effective without precipitating serious adverse effects. Conce...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/j.1875-9114.1986.tb03472.x
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND:Pharmacokinetic data show reduced mycophenolic acid levels in renal transplant recipients taking mycophenolate mofetil (MMF) and proton pump inhibitors (PPIs) concomitantly. This reduced exposure could increase rejection risk. The typical initial MMF dose post renal transplantation is 2 g/day, which often re...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2037
更新日期:2017-12-01 00:00:00
abstract:STUDY OBJECTIVE:To determine whether alvimopan for prevention of postoperative ileus in patients undergoing small- or large-bowel resection by laparotomy is associated with lower total costs compared with standard care. DESIGN:Pharmacoeconomic analysis using a formal decision model. DATA SOURCE:Four phase III clinica...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/PHAR.1047
更新日期:2012-02-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the activity of CYP2D6, N-acetylation, and xanthine oxidase, three drug-metabolizing enzyme systems, in patients with cystic fibrosis and compare the findings with those in individuals without the disease. DESIGN:Prospective cohort study. SETTING:General pediatrics service. PATIENTS:Fift...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::We cared for a patient in whom iron dextran administration interfered with the determination of total serum calcium concentration. An unexpected elevation in serum phosphorus concentration also occurred after the iron dextran infusion. A MEDLINE search from 1966 to present was conducted, and the manufacturer of the ir...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract::Skilled nursing facilities and nursing homes are care settings that offer increasing opportunities for pharmacists to take the lead when addressing the new updated Centers for Medicare and Medicaid Services (CMS) requirements coupled with enhanced quality measures reporting. In addition, the complexity of the medicati...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2155
更新日期:2018-08-01 00:00:00
abstract:STUDY OBJECTIVE:To describe the population pharmacokinetics and pharmacodynamic target attainment of ampicillin in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing controlled hypothermia (CH). DESIGN:Prospective, open-label pharmacokinetic study. SETTING:A 189-bed, freestanding children's tertiary care ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1916
更新日期:2017-04-01 00:00:00
abstract::The prevalence of diabetes mellitus has grown to staggering numbers, and its incidence is expected to rise in the next 2 decades. The need for novel approaches to treat hyperglycemia cannot be ignored. Current agents have been shown to modestly improve glycemia and in some cases prevent complications of diabetes, but ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/PHAR.1010
更新日期:2012-01-01 00:00:00
abstract::Clinicians are increasingly faced with the need to identify, treat, and counsel patients regarding psychotropic drug-induced sexual dysfunction. Antipsychotic and antidepressant drugs have both rational mechanisms to explain their effects on sexual function and established literature documenting these effects. The age...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.19.10.823.31553
更新日期:1999-07-01 00:00:00
abstract::Aspirin has been used for the prevention and treatment of cardiovascular disease (CVD) for several decades. The efficacy of aspirin for secondary prevention of cardiovascular disease is well established, but the clinical benefit of aspirin for primary prevention of CVD is less clear. The primary literature suggests th...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1127
更新日期:2012-11-01 00:00:00
abstract::Use of the Molecular Adsorbent Recirculating System (MARS) as a liver support device continues to grow worldwide. Various components of the MARS circuit remove both protein-bound and water-soluble molecules. Little is known about the extent of the enhanced clearance mechanisms used in MARS therapy on drug elimination....
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1618
更新日期:2015-08-01 00:00:00
abstract::Good admissions decisions are essential for identifying successful students and good practitioners. Various parameters have been shown to have predictive power for academic success. Previous academic performance, the Pharmacy College Admissions Test (PCAT), and specific prepharmacy courses have been suggested as acade...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.21.9.842.34566
更新日期:2001-07-01 00:00:00
abstract::The prevalence of cardiovascular risk factors continues to rise, with considerable emphasis on the upward trends in obesity and diabetes mellitus, which have increased by 46% and 60%, respectively, in the past 10 years. The alarming increase in the prevalence of diabetes and obesity has resulted in the development of ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.12part2.227S
更新日期:2006-12-01 00:00:00
abstract::Nucleoside analogs (zidovudine, didanosine, zalcitabine, stavudine, abacavir, lamivudine) have been administered as antiretroviral agents for more than a decade. They undergo anabolic phosphorylation by intracellular kinases to form triphosphates, which inhibit human immunodeficiency virus replication by competitively...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.21.1.11.34439
更新日期:2001-01-01 00:00:00
abstract::For convenience, many pediatric hospitals are preparing solutions for continuous nebulized albuterol using the 0.5% 20-ml multidose albuterol dropper bottle. This product contains benzalkonium chloride (BAC) that, by itself, produces bronchospasm that is dose dependent and cumulative. The bronchoconstrictive effects o...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1929
更新日期:2017-05-01 00:00:00
abstract::Many physiologic differences between children and adults can result in age-related differences in pharmacokinetics. Understanding the effects of age on bioavailability, volume of distribution, protein binding, hepatic metabolic isoenzymes, and renal elimination can provide insight into optimizing doses for pediatric p...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.29.6.680
更新日期:2009-06-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the number of women who have menopausal symptoms after discontinuing hormone therapy, to determine how many of these women subsequently require nonhormonal alternatives to manage their symptoms, and to assess the effectiveness of those therapies. DESIGN:One-year retrospective study. SETTI...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.10.1403
更新日期:2006-10-01 00:00:00
abstract:STUDY OBJECTIVE:To categorize institutional review board (IRB) challenges and solutions encountered in a multicenter practice-based research network (PBRN) study and to assess the impact of IRB requirements on the willingness of individual principal investigators (PIs) to participate in future PBRN studies. DESIGN:Des...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1276
更新日期:2013-09-01 00:00:00
abstract::The death rate from coronary heart disease (CHD) declined by 25% in the United States during 1987-1997, but the actual number of deaths fell by only 9%. Modifiable risk factors for CHD include hypertension, elevated low-density lipoprotein cholesterol, reduced high-density lipoprotein cholesterol, cigarette smoking, a...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.21.14.195s.34602
更新日期:2001-09-01 00:00:00
abstract::Contrast medium-induced nephrotoxicity (CMN) is a common form of iatrogenic acute renal failure. Typically, patients experience changes in serum creatinine or creatinine clearance between 1 and 5 days after exposure to a contrast medium, but they rarely require dialysis. The mechanism for CMN is not understood, but re...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.20.6.540.35154
更新日期:2000-05-01 00:00:00