Methotrexate in rheumatoid arthritis: an update.

abstract：:The primary objective of this study was to determine if a pharmacist-managed anticoagulation monitoring service (AMS) improved the outcomes of patients receiving warfarin in a family practice setting and was cost effective in treating and preventing thromboembolic disorders. A retrospective chart review was performed ...

journal_title：Pharmacotherapy

authors： Wilt VM,Gums JG,Ahmed OI,Moore LM

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Pharmacokinetic data show reduced mycophenolic acid levels in renal transplant recipients taking mycophenolate mofetil (MMF) and proton pump inhibitors (PPIs) concomitantly. This reduced exposure could increase rejection risk. The typical initial MMF dose post renal transplantation is 2 g/day, which often re...

journal_title：Pharmacotherapy

authors： Patel KS,Stephany BR,Barnes JF,Bauer SR,Spinner ML

更新日期：2017-12-01 00:00:00

abstract：:The efficacy of the sodium-glucose cotransporter 2 (SGLT2) inhibitors canagliflozin, dapagliflozin, and empagliflozin in reducing hyperglycemia in patients with type 2 diabetes is well documented. In addition, positive effects have been observed with these agents on nonglycemic variables, such as reductions in body we...

journal_title：Pharmacotherapy

authors： Trujillo JM,Nuffer WA

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:To compare changes in United States pharmacy practice faculty demographics from 1995-2001 and to discuss the implications for junior faculty development. METHODS:Demographic data were extracted from the American Association of Colleges of Pharmacy institutional research system for academic years 1995-1996 an...

journal_title：Pharmacotherapy

authors： Raehl CL

更新日期：2002-04-01 00:00:00

abstract：:Triclosan is a synthetic biocide found in many household products, including antimicrobial hand soap. Levels of triclosan have been found throughout the environment and in human urine, blood, and even breast milk. Increasing levels of exposure to triclosan have led to concerns over the development of resistance to tri...

journal_title：Pharmacotherapy

authors： Giuliano CA,Rybak MJ

更新日期：2015-03-01 00:00:00

abstract：:Meglumine antimoniate was administered to a patient with visceral leishmaniasis with normal renal function. Soon after the first intramuscular administration of meglumine antimoniate 20 mg/kg, equivalent to 510 mg antimony (Sb), the patient developed septic shock with oliguria. Creatinine clearance decreased to 23 ml/...

journal_title：Pharmacotherapy

authors： Hantson P,Luyasu S,Haufroid V,Lambert M

更新日期：2000-09-01 00:00:00

abstract：:The frequency of type 2 diabetes mellitus is increasing at an alarming rate. Prediabetes, also referred to as impaired glucose tolerance (IGT) and/or impaired fasting glucose, is a major risk factor for development of type 2 diabetes mellitus. In addition, IGT has been associated with an increased risk of cardiovascul...

journal_title：Pharmacotherapy

authors： Irons BK,Mazzolini TA,Greene RS

更新日期：2004-03-01 00:00:00

abstract：:The U.S. population continues to experience an alarmingly high rate of unintended pregnancies that have an impact on individual families and society alike. Lack of effective contraception accounts for most unintended pregnancies, along with incorrect use of contraceptives. The most common reversible contraceptive meth...

journal_title：Pharmacotherapy

authors： Rafie S,McIntosh J,Shealy KM,Borgelt LM,Forinash A,Shrader SP,Koepf ER,McClendon KS,Griffin BL,Horlen C,Karaoui LR,Rowe EL,Lodise NM,Wigle PR

更新日期：2014-09-01 00:00:00

abstract：:For convenience, many pediatric hospitals are preparing solutions for continuous nebulized albuterol using the 0.5% 20-ml multidose albuterol dropper bottle. This product contains benzalkonium chloride (BAC) that, by itself, produces bronchospasm that is dose dependent and cumulative. The bronchoconstrictive effects o...

journal_title：Pharmacotherapy

authors： Prabhakaran S,Abu-Hasan M,Hendeles L

更新日期：2017-05-01 00:00:00

abstract：:Target drug programs and medication use evaluations are activities that are undertaken to improve the correct use of drugs. These programs should focus on inappropriate drug use, drug use problems, optimizing use of drugs, and improving the level of patient care. To monitor the effects of the programs, several types o...

journal_title：Pharmacotherapy

authors： Hekster YA

更新日期：2000-10-01 00:00:00

abstract：:Hormonal emergency contraceptives have been used to prevent unwanted pregnancy for more than 3 decades. The mechanisms of action of the regimen containing a combination of estrogen and progestin, known as the Yuzpe regimen, and those of the levonorgestrel regimen continue to be controversial, especially over the possi...

journal_title：Pharmacotherapy

authors： Leung VW,Levine M,Soon JA

更新日期：2010-02-01 00:00:00

abstract：:A 40-month-old child was sedated with a fentanyl and midazolam infusion for 7 days. After the drugs were discontinued he became unresponsive and globally aphasic, and had marked thrombocytosis. He was hospitalized for 4 weeks, during which time his motor and cognitive status slowly improved, and had almost returned to...

journal_title：Pharmacotherapy

authors： Ducharme MP,Munzenberger P

更新日期：1995-09-01 00:00:00

abstract：:During the past decade, the incidence and severity of Clostridium difficile infection (CDI) have significantly increased, leading to a rise in CDI-associated hospitalizations, health care costs, and mortality. Although treatment options exist for CDI, recurrence is frequent following treatment. Furthermore, patients w...

journal_title：Pharmacotherapy

authors： Kufel WD,Devanathan AS,Marx AH,Weber DJ,Daniels LM

更新日期：2017-10-01 00:00:00

abstract：:Central nervous system stimulants are a commonly used first-line treatment option for attention-deficit/hyperactivity disorder (ADHD). Stimulants are generally well tolerated, with anorexia and insomnia the most common adverse effects. However, there are some concerns with long-term use of stimulants, such as potentia...

journal_title：Pharmacotherapy

authors： Troksa K,Kovacich N,Moro M,Chavez B

更新日期：2019-06-01 00:00:00

abstract：:The use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) has significantly reduced morbidity and mortality across the continuum of vascular disease. The utilization of these agents, however, remains suboptimal. The drugs are not prescribed in many patients because of concerns ...

journal_title：Pharmacotherapy

authors： Epstein BJ

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:Twice/day dosing of insulin glargine has been used to treat hyperglycemia in clinical practice; however, data supporting its use in the critically ill population are lacking. This study was designed to evaluate the safety and efficacy of twice/day insulin glargine in critically ill patients. METHODS:A retros...

journal_title：Pharmacotherapy

authors： Fox MA,Perry MC,Liu-DeRyke X

更新日期：2020-03-01 00:00:00

abstract：:Peripheral blood has replaced bone marrow as a source of hematopoietic stem cells for autologous rescue after high-dose chemotherapy. Patients who receive peripheral blood stem cell (PBSC) transplants experience rapid and sustained hematopoietic reconstitution. As a result, transplant-related mortality is now less tha...

journal_title：Pharmacotherapy

authors： Yee GC

更新日期：1996-05-01 00:00:00

abstract：:The immune system is a complex network of components functioning to provide host defense. This network consists of immunologic cells and their products (e.g., interleukins and colony-stimulating factors), organs, tissues, complement, and major histocompatibility complex antigens. These components are organized into sp...

journal_title：Pharmacotherapy

authors： McIntyre WJ,Tami JA

更新日期：1992-01-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the pharmacokinetic profile of palifermin after intravenous dosing with either a collapsed dose of 180 microg/kg/day for 1 day or a standard dose of 60 microg/kg/day for 3 days, before and after myeloablative chemoradiotherapy and peripheral blood progenitor cell (PBPC) transplantation. DESIG...

journal_title：Pharmacotherapy

authors： Zia-Amirhosseini P,Hurd DD,Salfi M,Cheah TC,Aycock J,Cesano A

更新日期：2007-10-01 00:00:00

abstract：:We sought to summarize and assess original evaluations of the economic impact of clinical pharmacy services published from 1996-2000, and to provide recommendations and methodologic considerations for future research. A systematic literature search was conducted to identify articles that were then blinded and randomly...

journal_title：Pharmacotherapy

authors： Schumock GT,Butler MG,Meek PD,Vermeulen LC,Arondekar BV,Bauman JL,2002 Task Force on Economic Evaluation of Clinical Pharmacy Services of the American College of Clinical Pharmacy.

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:In an era of increasing polypharmacy, adverse drug effects such as ototoxicity have significant public health implications. Despite the availability of evidence, many health care professionals may not know the risk of ototoxicity in common medications. Therefore, the aim of this review is to provide a compreh...

journal_title：Pharmacotherapy

authors： Rizk HG,Lee JA,Liu YF,Endriukaitis L,Isaac JL,Bullington WM

更新日期：2020-12-01 00:00:00

abstract：STUDY OBJECTIVE:To characterize a time-dependent disposition of oral tacrolimus and its relationship with plasma endothelin-1 concentrations. DESIGN:Randomized, crossover study. SETTING:Clinical research center of a university-affiliated hospital. PATIENTS:Twelve stable liver transplant recipients. INTERVENTIONS:In...

journal_title：Pharmacotherapy

authors： Min DI,Chen HY,Lee MK,Ashton K,Martin MF

更新日期：1997-05-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effect of Niaspan--a niacin preparation with both immediate- and extended-release characteristics--on lipid and glycemic control in patients with type 2 diabetes. DESIGN:Retrospective study SETTING:Private-practice endocrinology group. PATIENTS:Thirty-two patients (mean age 60 yrs; 7...

journal_title：Pharmacotherapy

authors： Kane MP,Hamilton RA,Addesse E,Busch RS,Bakst G

更新日期：2001-12-01 00:00:00

abstract：:The pharmacokinetics of methylprednisolone sodium succinate (MPHS) and methylprednisolone (MP) were determined in six patients undergoing open heart surgery with cardiopulmonary bypass. Plasma concentrations of both compounds were measured by high-performance liquid chromatography after doses of MPHS of 1.7-2.4 g. The...

journal_title：Pharmacotherapy

authors： Kong AN,Jungbluth GL,Pasko MT,Beam TR,Jusko WJ

更新日期：1990-01-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the activity of CYP2D6, N-acetylation, and xanthine oxidase, three drug-metabolizing enzyme systems, in patients with cystic fibrosis and compare the findings with those in individuals without the disease. DESIGN:Prospective cohort study. SETTING:General pediatrics service. PATIENTS:Fift...

journal_title：Pharmacotherapy

authors： Bosso JA,Liu Q,Evans WE,Relling MV

更新日期：1996-09-01 00:00:00

abstract：STUDY OBJECTIVE:To perform a cost-effectiveness analysis comparing three treatment approaches during nonurgent percutaneous coronary intervention (PCI): bivalirudin with provisional glycoprotein (GP) IIb-IIIa inhibitor therapy, unfractionated heparin (UFH) with eptifibatide, and UFH with abciximab. DESIGN:Literature-b...

journal_title：Pharmacotherapy

authors： Summers KM,Holdford DA,Crouch MA

更新日期：2006-05-01 00:00:00

abstract：:The Institute of Medicine has identified adverse drug events as factors that significantly contribute to increased patient morbidity and mortality. As critically ill patients receive numerous drugs to treat a multitude of complicated health problems, they are at high risk for adverse drug events. Sedation is often a k...

journal_title：Pharmacotherapy

authors： Corbett SM,Montoya ID,Moore FA

更新日期：2008-02-01 00:00:00

abstract：:A 58-year-old woman who had been taking digoxin 0.25 mg/day for more than 35 years for heart palpitations after mitral valve repair was prescribed a 5-day course of telithromycin for acute bronchitis. On the sixth day of therapy, she came to the emergency department complaining of general malaise and having experience...

journal_title：Pharmacotherapy

authors： Nenciu LM,Laberge P,Thirion DJ

更新日期：2006-06-01 00:00:00

abstract：:A 58-year-old man experienced an asthma exacerbation after administration of nicotine nasal spray for smoking cessation. His medical history was significant for asthma, chronic obstructive pulmonary disease, hypertension, and tobacco use when he was prescribed nicotine nasal spray for smoking cessation in an outpatien...

journal_title：Pharmacotherapy

authors： Roth MT,Westman EC

更新日期：2002-06-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the impact of having an antimicrobial allergy label in the medical record on clinical outcomes in hospitalized patients. DESIGN:Retrospective cohort study. SETTING:Urban academic teaching hospital. PATIENTS:A total of 11,872 adults admitted to nonsurgical patient care wards who received ...

journal_title：Pharmacotherapy

authors： Charneski L,Deshpande G,Smith SW

更新日期：2011-08-01 00:00:00