Pharmacokinetics of daptomycin in a critically ill adolescent with vancomycin-resistant enterococcal endocarditis.

Abstract:

:Daptomycin is a lipopeptide antibiotic active against multidrug-resistant gram-positive organisms. Our search of the literature found no published pediatric pharmacokinetic data. We report the use of pharmacokinetic analysis of daptomycin in a 13-year-old boy with vancomycin-resistant Enterococcus faecium endocarditis. Pharamcokinetic parameters were found to be significantly different from published adult parameters, such as a faster elimination rate, shorter half-life, and increased clearance. These age-related differences in the pharmacokinetic profile of daptomycin have significant dosing implications. As the use of this drug for off-label indications and in pediatric populations increases, it is important for clinicians to better understand the drug's pharmacokinetic profile in these patient populations.

journal_name

Pharmacotherapy

journal_title

Pharmacotherapy

authors

Akins RL,Haase MR,Levy EN

doi

10.1592/phco.26.5.694

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

694-8

issue

5

eissn

0277-0008

issn

1875-9114

journal_volume

26

pub_type

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