Pharmacokinetics of daptomycin in a critically ill adolescent with vancomycin-resistant enterococcal endocarditis.


:Daptomycin is a lipopeptide antibiotic active against multidrug-resistant gram-positive organisms. Our search of the literature found no published pediatric pharmacokinetic data. We report the use of pharmacokinetic analysis of daptomycin in a 13-year-old boy with vancomycin-resistant Enterococcus faecium endocarditis. Pharamcokinetic parameters were found to be significantly different from published adult parameters, such as a faster elimination rate, shorter half-life, and increased clearance. These age-related differences in the pharmacokinetic profile of daptomycin have significant dosing implications. As the use of this drug for off-label indications and in pediatric populations increases, it is important for clinicians to better understand the drug's pharmacokinetic profile in these patient populations.






Akins RL,Haase MR,Levy EN




Has Abstract


2006-05-01 00:00:00












  • Risk Factors for Voriconazole-Associated Hepatotoxicity in Patients in the Intensive Care Unit.

    abstract:STUDY OBJECTIVES:To determine the incidence of hepatotoxicity in critically ill patients who were treated with voriconazole and to identify potential risk factors for voriconazole-associated hepatotoxicity in these patients. DESIGN:Single-center prospective observational study. SETTING:Intensive care unit (ICU) in a ...


    pub_type: 杂志文章


    authors: Wang Y,Wang T,Xie J,Yang Q,Zheng X,Dong W,Xing J,Wang X,Dong Y

    更新日期:2016-07-01 00:00:00

  • Prevention of Clostridium difficile Infection in Critically Ill Adults.

    abstract::The incidence and severity of Clostridium difficile infection (CDI) remain high across intensive care units in the United States despite national efforts to decrease this escalating health care burden. Most published literature and guidelines address treatment rather than prevention, yet this approach may be too downs...


    pub_type: 杂志文章,评审


    authors: Leedahl DD,Personett HA,Nagpal A,Barreto EF

    更新日期:2019-03-01 00:00:00

  • High-performance capillary electrophoresis in the pharmaceutical sciences.

    abstract::High-performance capillary electrophoresis (HPCE) is a new separation technique that is applied in the pharmaceutical sciences. Separations by HPCE occur in a narrow-bore capillary under the influence of an applied electrical field. Components of the sample matrix are separated and migrate at different rates based on ...


    pub_type: 杂志文章,评审


    authors: Brunner LJ,DiPiro JT,Feldman S

    更新日期:1995-01-01 00:00:00

  • Hepatic drug metabolism in critical illness.

    abstract::Hepatic drug metabolism is altered in critically ill patients. The etiology and mechanisms of the alterations are not clearly understood and are difficult to address in clinical studies. For this reason, in vitro and animal models were developed to investigate the effects of critical illness on hepatic drug metabolism...


    pub_type: 杂志文章,评审


    authors: McKindley DS,Hanes S,Boucher BA

    更新日期:1998-07-01 00:00:00

  • Early Administration of Adjuvant β-Lactam Therapy in Combination with Vancomycin among Patients with Methicillin-Resistant Staphylococcus aureus Bloodstream Infection: A Retrospective, Multicenter Analysis.

    abstract:STUDY OBJECTIVE:To determine whether early administration of adjuvant β-lactam in combination with vancomycin (COMBO) affects clinical outcomes compared to standard vancomycin therapy alone (STAN) among patients with methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection. DESIGN:Retrospective, multic...


    pub_type: 杂志文章,多中心研究


    authors: Casapao AM,Jacobs DM,Bowers DR,Beyda ND,Dilworth TJ,REACH-ID Study Group.

    更新日期:2017-11-01 00:00:00

  • Delaying the onset of type 2 diabetes mellitus in patients with prediabetes.

    abstract::The frequency of type 2 diabetes mellitus is increasing at an alarming rate. Prediabetes, also referred to as impaired glucose tolerance (IGT) and/or impaired fasting glucose, is a major risk factor for development of type 2 diabetes mellitus. In addition, IGT has been associated with an increased risk of cardiovascul...


    pub_type: 杂志文章,评审


    authors: Irons BK,Mazzolini TA,Greene RS

    更新日期:2004-03-01 00:00:00

  • Diflunisal in the treatment of the pain of osteoarthritis. Summary of clinical studies.

    abstract::In comprehensive clinical studies, diflunisal--a new nonsteroidal antiinflammatory drug with a long duration of action--was shown to be highly effective and generally well tolerated in the short- and long-term treatment of the pain of osteoarthritis. In double-blind comparison studies, diflunisal was comparable in eff...


    pub_type: 临床试验,杂志文章


    authors: Umbenhauer ER

    更新日期:1983-03-01 00:00:00

  • Discontinuation of antihypertensive drugs due to adverse events: a systematic review and meta-analysis.

    abstract::We conducted a systematic review of randomized, controlled, monotherapy trials since 1990 of oral antihypertensive agents in patients with essential hypertension. Our objective was to quantify the frequency of discontinuation of antihypertensive agents due to adverse events from a meta-analysis of the studies. A total...


    pub_type: 杂志文章,meta分析


    authors: Ross SD,Akhras KS,Zhang S,Rozinsky M,Nalysnyk L

    更新日期:2001-08-01 00:00:00

  • Physician-pharmacist comanagement of hypertension: a randomized, comparative trial.

    abstract:OBJECTIVE:To compare the effectiveness of an evidence-based, systematic approach to hypertension care involving comanagement of patients by primary care physicians and clinical pharmacists versus usual care in reducing blood pressure in patients with uncontrolled hypertension. METHODS:Patients in a staff model medical...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Borenstein JE,Graber G,Saltiel E,Wallace J,Ryu S,Archi J,Deutsch S,Weingarten SR

    更新日期:2003-02-01 00:00:00

  • Graves' Disease Pharmacotherapy in Women of Reproductive Age.

    abstract::Graves' disease is an autoimmune disorder in which inappropriate stimulation of the thyroid gland results in unregulated secretion of thyroid hormones resulting in hyperthyroidism. Graves' disease is the most common cause of autoimmune hyperthyroidism during pregnancy. Treatment options for Graves' disease include thi...


    pub_type: 杂志文章,评审


    authors: Prunty JJ,Heise CD,Chaffin DG

    更新日期:2016-01-01 00:00:00

  • More stable and reliable pharmacokinetics with preprandial administration of cyclosporine compared with postprandial administration in patients with refractory nephrotic syndrome.

    abstract:STUDY OBJECTIVE:To compare the absorption profile of cyclosporine after preprandial administration with that after postprandial administration, and to determine which administration time resulted in a more stable absorption profile and the timing of the drug concentration that was the most reliable marker for monitorin...


    pub_type: 杂志文章


    authors: Kusaba T,Konno Y,Hatta S,Fujino T,Yasuda T,Miura H,Sasaki H,Okabayashi J,Murao M,Sakurada T,Imai G,Shirai S,Kuboshima S,Shima Y,Ogimoto G,Sato T,Masuhara K,Kimura K

    更新日期:2005-01-01 00:00:00

  • Management of Pediatric Acute Hematogenous Osteomyelitis, Part II: A Focus on Methicillin-Resistant Staphylococcus aureus, Current and Emerging Therapies.

    abstract::Methicillin-resistant Staphylococcus aureus (MRSA) has become the most prevalent cause of acute hematogenous osteomyelitis (AHO) in pediatric patients. This increase in MRSA is due to the rise in community-acquired MRSA. Therefore, it is important that clinicians are aware of the various and upcoming therapies that co...


    pub_type: 杂志文章,评审


    authors: DeRonde KJ,Girotto JE,Nicolau DP

    更新日期:2018-10-01 00:00:00

  • The effect of theophylline on respiratory muscle contractility and fatigue.

    abstract::The traditional role of theophylline as a bronchodilator has been expanded by recent findings that suggest this drug has more than smooth muscle relaxant properties. Several investigators indicate that theophylline has an inotropic effect on respiratory muscle, causing enhanced muscular contraction and prevention of m...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Landsberg KF,Vaughan LM,Heffner JE

    更新日期:1990-01-01 00:00:00

  • Follow-up of adverse drug reactions from peginterferon alfa-2b-ribavirin therapy.

    abstract:STUDY OBJECTIVE:To investigate the adverse drug reactions (ADRs) from peginterferon alfa-2b plus ribavirin in patients infected with the hepatitis C virus (HCV). DESIGN:Prospective, observational, pharmacovigilance study. SETTING:Gastroenterology department of a French university hospital. PATIENTS:A cohort of conse...


    pub_type: 杂志文章


    authors: Bagheri H,Fouladi A,Barange K,Lapeyre-Mestre M,Payen JL,Montastruc JL,Vinel JP

    更新日期:2004-11-01 00:00:00

  • Deprescribing: An Application to Medication Management in Older Adults.

    abstract::Polypharmacy has been found to have potentially negative consequences for patients due to use of potentially inappropriate medications, as well as increased risk of drug interactions and adverse effects. Deprescribing has been proposed as a method of improving medication use throughout a patient's course of care. This...


    pub_type: 杂志文章,评审


    authors: Bemben NM

    更新日期:2016-07-01 00:00:00

  • Cannabis for Chronic Pain: Challenges and Considerations.

    abstract::The National Academies of Sciences, Engineering, and Medicine has found substantial evidence that cannabis (plant) is effective for the treatment of chronic pain in adults, and moderate evidence that oromucosal cannabinoids (extracts, especially nabiximols) improve short-term sleep disturbances in chronic pain. The pa...


    pub_type: 杂志文章,评审


    authors: Romero-Sandoval EA,Fincham JE,Kolano AL,Sharpe BN,Alvarado-Vázquez PA

    更新日期:2018-06-01 00:00:00

  • Etomidate: a new intravenous anesthetic induction agent.

    abstract::Currently available anesthetic induction agents provide adequate hypnosis but are not ideal, particularly in the high risk patient (ASA class III-V), because most cause myocardial and/or respiratory depression and some have other important side effects. Etomidate was recently marketed as an intravenous anesthetic indu...


    pub_type: 杂志文章,评审


    authors: Giese JL,Stanley TH

    更新日期:1983-09-01 00:00:00

  • Neurotoxicity associated with ceftazidime therapy in geriatric patients with renal dysfunction.

    abstract::Ceftazidime, a beta-lactamase-stable, third-generation cephalosporin, is widely used for the treatment of serious gram-negative infections. Neurotoxicity has rarely been associated with the drug; however, two of our patients developed ceftazidime-induced neurotoxicity that produced confusion, disorientation, agitation...


    pub_type: 杂志文章


    authors: Slaker RA,Danielson B

    更新日期:1991-01-01 00:00:00

  • Comparison of bivalirudin and argatroban for the management of heparin-induced thrombocytopenia.

    abstract:STUDY OBJECTIVES:To compare the effectiveness of bivalirudin and argatroban in achieving anticoagulation goals and to compare clinical outcomes assessing the safety and efficacy in patients with known or suspected heparin-induced thrombocytopenia (HIT). DESIGN:Single-center, retrospective analysis. SETTING:Large tert...


    pub_type: 杂志文章


    authors: Skrupky LP,Smith JR,Deal EN,Arnold H,Hollands JM,Martinez EJ,Micek ST

    更新日期:2010-12-01 00:00:00

  • Evaluation and Treatment of Acute and Subacute Hearing Loss: A Review of Pharmacotherapy.

    abstract::Among various forms of hearing loss, there are acute (within 72 hrs) or subacute (weeks to months) presentations that may be reversible with early pharmacological intervention. The workup of a patient presenting with hypoacusia includes the usual history and physical examination in conjunction with an audiometric asse...


    pub_type: 杂志文章,评审


    authors: Fazel MT,Jedlowski PM,Cravens RB Jr,Erstad BL

    更新日期:2017-12-01 00:00:00

  • Falsely decreased total serum calcium concentration associated with iron dextran injection.

    abstract::We cared for a patient in whom iron dextran administration interfered with the determination of total serum calcium concentration. An unexpected elevation in serum phosphorus concentration also occurred after the iron dextran infusion. A MEDLINE search from 1966 to present was conducted, and the manufacturer of the ir...


    pub_type: 杂志文章


    authors: Newsom L,Erstad BL,Nakazato PZ,Daller JA

    更新日期:1995-11-01 00:00:00

  • Prolonged, but not diminished, zidovudine absorption induced by a high-fat breakfast.

    abstract:STUDY OBJECTIVE:To determine the effect of a high-fat breakfast on single-dose, zidovudine (ZDV) pharmacokinetics. DESIGN:Open-label, randomized, crossover study. PATIENTS:Eighteen asymptomatic subjects (12 men, 6 women) infected with the human immunodeficiency virus (mean CD4 cell counts of 512 +/- 178/mm3). INTERV...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Shelton MJ,Portmore A,Blum MR,Sadler BM,Reichman RC,Morse GD

    更新日期:1994-11-01 00:00:00

  • Key articles and guidelines for the prevention of venous thromboembolism.

    abstract::Venous thromboembolism (VTE) is an important medical problem that affects millions of patients each year. With appropriate prophylaxis, many of these thromboembolic events can be prevented. Although strong evidence supporting VTE prophylaxis spans several decades, several large American and global registries have docu...




    authors: Dobesh PP,Wittkowsky AK,Stacy Z,Dager WE,Haines ST,Lopez LM,Nutescu E,Phillips KW,Trujillo TC,Vondracek T

    更新日期:2009-04-01 00:00:00

  • Cerivastatin-induced rhabdomyolysis: 11 case reports.

    abstract::3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a frequently prescribed class of drugs that are generally well tolerated by most patients. A rare, yet serious side effect associated with these drugs is rhabdomyolysis. Although all HMG-CoA reductase inhibitors can cause this adverse effect, pre...


    pub_type: 杂志文章,评审


    authors: Ravnan SL,Locke C,Yee WP,Haase K

    更新日期:2002-04-01 00:00:00

  • Population Pharmacokinetics and Pharmacodynamic Target Attainment of Ampicillin in Neonates with Hypoxemic-Ischemic Encephalopathy in the Setting of Controlled Hypothermia.

    abstract:STUDY OBJECTIVE:To describe the population pharmacokinetics and pharmacodynamic target attainment of ampicillin in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing controlled hypothermia (CH). DESIGN:Prospective, open-label pharmacokinetic study. SETTING:A 189-bed, freestanding children's tertiary care ...


    pub_type: 杂志文章


    authors: Cies JJ,Fugarolas KN,Moore WS 2nd,Mason RW,Menkiti OR

    更新日期:2017-04-01 00:00:00

  • Insulin glargine and cancer risk: an opinion statement of the Endocrine and Metabolism Practice and Research Network of the American College of Clinical Pharmacy.

    abstract::Diabetes mellitus has reached epidemic proportions worldwide, eliciting extensive research on both the disease process and its treatment. Regardless of diabetes type, the progressive nature of the disease makes insulin the long-term mainstay of diabetes management. Recently, the insulin analog glargine was reported in...


    pub_type: 杂志文章,实务指引


    authors: Edwards KL,Riche DM,Stroup JS,Goldman-Levine JD,Padiyara RS,Cross LB,Kane MP

    更新日期:2010-09-01 00:00:00

  • Current options in antifungal pharmacotherapy.

    abstract::Infections caused by yeasts and molds continue to be associated with high rates of morbidity and mortality in both immunocompromised and immunocompetent patients. Many antifungal drugs have been developed over the past 15 years to aid in the management of these infections. However, treatment is still not optimal, as t...


    pub_type: 杂志文章,评审


    authors: Mohr J,Johnson M,Cooper T,Lewis JS,Ostrosky-Zeichner L

    更新日期:2008-05-01 00:00:00

  • Insulin Glargine in Critically ill Patients: Once/Day versus Twice/Day Dosing.

    abstract:OBJECTIVE:Twice/day dosing of insulin glargine has been used to treat hyperglycemia in clinical practice; however, data supporting its use in the critically ill population are lacking. This study was designed to evaluate the safety and efficacy of twice/day insulin glargine in critically ill patients. METHODS:A retros...


    pub_type: 杂志文章


    authors: Fox MA,Perry MC,Liu-DeRyke X

    更新日期:2020-03-01 00:00:00

  • Enhanced metabolism of levonorgestrel during phenobarbital treatment and resultant pregnancy.

    abstract::Levonorgestrel implants (Norplant) are an alternative to oral contraceptives and medroxyprogesterone acetate intramuscular injections. An interaction may exist between levonorgestrel and agents that induce the hepatic microsomal enzyme system. A 21-year-old woman with a history of a seizure disorder, treated with phen...


    pub_type: 杂志文章


    authors: Shane-McWhorter L,Cerveny JD,MacFarlane LL,Osborn C

    更新日期:1998-11-01 00:00:00

  • Integrase Inhibitors: After 10 Years of Experience, Is the Best Yet to Come?

    abstract::The era of the integrase strand transfer inhibitors (INSTIs) for the treatment of human immunodeficiency virus (HIV) infection began with raltegravir in 2007. Since that time, several other INSTIs have been introduced including elvitegravir, dolutegravir, and, most recently, bictegravir, that have shown great utility ...


    pub_type: 杂志文章,评审


    authors: Brooks KM,Sherman EM,Egelund EF,Brotherton A,Durham S,Badowski ME,Cluck DB

    更新日期:2019-05-01 00:00:00