Diurnal variation in plasma norepinephrine in patients with heart failure.

abstract：:In critically ill patients with acute renal failure, continuous arteriovenous hemodiafiltration (CAVHD) has become an increasing popular supportive technique. An adult with acute renal failure during CAVHD therapy received fluconazole. Drug clearance by the hemodiafilter system and its total body clearance during the ...

journal_title：Pharmacotherapy

authors： Nicolau DP,Crowe H,Nightingale CH,Quintiliani R

更新日期：1994-07-01 00:00:00

abstract：:Intravenous unfractionated heparin (UFH) remains an important therapeutic agent, particularly in the inpatient setting, for anticoagulation. Historically, the activated partial thromboplastin time (aPTT) has been the primary laboratory test used to monitor and adjust UFH. The aPTT test has evolved since the 1950s, and...

journal_title：Pharmacotherapy

authors： Vandiver JW,Vondracek TG

更新日期：2012-06-01 00:00:00

abstract：:Omadacycline is a novel aminomethylcycline approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. This article reviews existing data pertaining to the biochemistry, mechanism of action, pharmacokinetics/pharmacodynamics, in vitro activity, and curre...

journal_title：Pharmacotherapy

authors： Barber KE,Bell AM,Wingler MJB,Wagner JL,Stover KR

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Neurocritically ill patients have clinically significant alterations in pharmacokinetic parameters of renally eliminated medications that may result in subtherapeutic plasma and cerebrospinal fluid antibiotic concentrations. METHODS:We conducted a prospective randomized open-label study of adult neurocriticall...

journal_title：Pharmacotherapy

authors： Kassel LE,Van Matre ET,Foster CJ,Fish DN,Mueller SW,Sherman DS,Wempe MF,MacLaren R,Neumann RT,Kiser TH

更新日期：2018-09-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the usage patterns of the lipid-based amphotericin B formulations at our institution and to compare the observed nephrotoxicity and efficacy of these formulations. DESIGN:Prospective and retrospective observational study SETTING:Urban 350-bed teaching hospital. PATIENTS:Sixty-seven nonhe...

journal_title：Pharmacotherapy

authors： Cannon JP,Garey KW,Danziger LH

更新日期：2001-09-01 00:00:00

abstract：:Little information has been published concerning differences among the benzodiazepines in treating hospitalized patients with severe symptoms of alcohol withdrawal. We attempted to determine the length and type of hospital stay, and the pattern and appropriateness of administration, dosage requirements, and costs asso...

journal_title：Pharmacotherapy

authors： Hoey LL,Nahum A,Vance-Bryan K

更新日期：1994-09-01 00:00:00

abstract：:A 43-year-old man with a 19-year history of Crohn's disease experienced serum sickness with acute lobular panniculitis and vasculitis within 2 weeks of initiating 6-mercaptopurine therapy. He had no history of extraintestinal manifestations of Crohn's disease or drug allergy. Symptoms included disabling joint pain, pr...

journal_title：Pharmacotherapy

authors： Andersen JM,Tiede JJ

更新日期：1997-01-01 00:00:00

abstract：:This commentary from the 2010 Task Force on Acute Care Practice Model of the American College of Clinical Pharmacy was developed to compare and contrast the "unit-based" and "service-based" orientation of the clinical pharmacist within an acute care pharmacy practice model and to offer an informed opinion concerning w...

journal_title：Pharmacotherapy

authors： American College of Clinical Pharmacy.,Haas CE,Eckel S,Arif S,Beringer PM,Blake EW,Lardieri AB,Lobo BL,Mercer JM,Moye P,Orlando PL,Wargo K

更新日期：2012-02-01 00:00:00

abstract：:Fatigue is one of the most debilitating and common symptoms associated with hematologic and oncologic disorders and treatment strategies. Patient factors influence etiology and symptom manifestation, which in turn affect diagnosis, management, and monitoring. Fatigue instruments can assist with the identification, man...

journal_title：Pharmacotherapy

authors： Schwartz AH

更新日期：2002-11-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the pharmacodynamics of four intravenous antimicrobial regimens-ceftriaxone 1 g, gatifloxacin 400 mg, levofloxacin 500 mg, and levofloxacin 750 mg, each every 24 hours-against recent Streptococcus pneumoniae isolates. DESIGN:Pharmacodynamic analysis using Monte Carlo simulation. DATA SOURC...

journal_title：Pharmacotherapy

authors： Frei CR,Burgess DS

更新日期：2005-09-01 00:00:00

abstract：STUDY OBJECTIVE:To assess patients' perception of care delivery by anticoagulation clinics (ACs) throughout Alberta, Canada. DESIGN:Prospective postal survey. SETTING:Therapy provision by an AC to ambulatory-based patients for a minimum of 3 months across the province. PATIENTS:A total of 1687 patients (67.9%) recei...

journal_title：Pharmacotherapy

authors： Bungard TJ,Barry AR,Jones C,Brocklebank C

更新日期：2013-11-01 00:00:00

abstract：:Clopidogrel decreases the morbidity and mortality associated with several cardiovascular diseases. However, clopidogrel is a prodrug that needs to be metabolized to the active thiol metabolite by the cytochrome P450 (CYP) system. This activation is a source of significant interindividual variability in clopidogrel res...

journal_title：Pharmacotherapy

authors： Momary KM,Dorsch MP,Bates ER

更新日期：2010-03-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the effects of atorvastatin on low-density lipoprotein cholesterol (LDL) particle size and C-reactive protein (CRP) concentrations in patients undergoing long-term hemodialysis. Another objective was to compare the effects of atorvastatin on lipoprotein profiles as determined by direct ver...

journal_title：Pharmacotherapy

authors： Dornbrook-Lavender KA,Joy MS,Denu-Ciocca CJ,Chin H,Hogan SL,Pieper JA

更新日期：2005-03-01 00:00:00

abstract：:Patients who experienced pain after surgery were administered a single dose of 1 of 3 treatments: acetaminophen 1000 mg, codeine phosphate 60 mg, or a combination of these. Patients rated their pain intensity on ordinal and visual analog scales just prior to medication and at intervals thereafter for up to 5 hours. Th...

journal_title：Pharmacotherapy

authors： Gertzbein SD,Tile M,McMurty RY,Kellam JF,Hunter GA,Keith RG,Harsanyi Z,Luffman J

更新日期：1986-05-01 00:00:00

abstract：:This study documents a pharmacokinetic interaction between carbamazepine and cyclosporine (CsA) in pediatric renal transplant recipients. Noncompartmental steady-state CsA pharmacokinetics were determined in three pediatric renal transplant recipients who were receiving both CsA and carbamazepine as long-term therapy ...

journal_title：Pharmacotherapy

authors： Cooney GF,Mochon M,Kaiser B,Dunn SP,Goldsmith B

更新日期：1995-05-01 00:00:00

abstract：:A 26-year-old woman developed significant unilateral anterior cervical and supraclavicular lymphadenopathy 3 days after receiving her first dose (of a total of three doses) of human papilloma virus (HPV) vaccine. She had no history of lymphadenopathy after other previous immunizations, and had received no vaccines oth...

journal_title：Pharmacotherapy

authors： Studdiford J,Lamb K,Horvath K,Altshuler M,Stonehouse A

更新日期：2008-09-01 00:00:00

abstract：:Antiretroviral therapy has significantly improved the typical course of human immunodeficiency virus (HIV) infection in industrialized nations, and life expectancies associated with the infection have increased. However, infection rates have generally remained unchanged, with increases noted among certain subpopulatio...

journal_title：Pharmacotherapy

authors： Romanelli F,Murphy B

更新日期：2010-10-01 00:00:00

abstract：:The purpose of the American College of Clinical Pharmacy (ACCP) is to advance human health by extending the frontiers of clinical pharmacy. Consistent with this mission and its core values, ACCP is committed to ensuring that clinical pharmacists possess the knowledge, skills, attitudes, and behaviors necessary to deli...

journal_title：Pharmacotherapy

authors： Saseen JJ,Ripley TL,Bondi D,Burke JM,Cohen LJ,McBane S,McConnell KJ,Sackey B,Sanoski C,Simonyan A,Taylor J,Vande Griend JP

更新日期：2017-05-01 00:00:00

abstract：STUDY OBJECTIVES:To identify subsequent therapies used after first-line therapies in patients with advanced non-small cell lung cancer (NSCLC), compare overall survival (OS) associated with subsequent therapies, and evaluate factors associated with OS in these patients. METHODS:The study was a retrospective cohort ana...

journal_title：Pharmacotherapy

authors： Afanasjeva J,Hui RL,Spence MM,Chang J,Schottinger JE,Millares M,Rashid N

更新日期：2016-10-01 00:00:00

abstract：:Ziconotide intrathecal infusion was recently approved by the United States Food and Drug Administration for the treatment of intractable severe chronic pain. Patients with neuropathic pain make up a significant population among those who experience chronic pain for which there are less than optimal pharmacotherapeutic...

journal_title：Pharmacotherapy

authors： Wermeling DP,Berger JR

更新日期：2006-03-01 00:00:00

abstract：:Status epilepticus (SE) has a high mortality rate and is one of the most common neurologic emergencies. Fast progression of this neurologic emergency and lack of response to traditional antiepileptic drugs (AEDs) in most cases has challenged clinicians to use new agents. This article evaluates the efficacy and safety ...

journal_title：Pharmacotherapy

authors： Farrokh S,Bon J,Erdman M,Tesoro E

更新日期：2019-03-01 00:00:00

abstract：STUDY OBJECTIVE:To develop and evaluate a peer review group (PRG) meeting using feedback data on a patient level to improve the quality of drug therapy for prevention of recurrent myocardial infarction. DESIGN:Prospective follow-up study. DATA SOURCE:General practitioners' computerized patients records (intervention ...

journal_title：Pharmacotherapy

authors： van der Elst ME,Bouvy ML,de Blaey CJ,de Boer A

更新日期：2006-02-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate claims-related treatment adherence, health care resource utilization, and associated costs of therapy conversion from an insulin vial and syringe to a premixed biphasic insulin analog pen device among privately insured patients with type 2 diabetes mellitus. DESIGN:Retrospective, longitudin...

journal_title：Pharmacotherapy

authors： Cobden D,Lee WC,Balu S,Joshi AV,Pashos CL

更新日期：2007-07-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV) has resulted in significant morbidity and mortality reductions. Lifelong antiretroviral therapy must be incorporated into each patient's medical regimen. Patients with HIV may also have simultaneous chronic medical conditions, resultin...

journal_title：Pharmacotherapy

authors： Fulco PP,Zingone MM,Higginson RT

更新日期：2008-07-01 00:00:00

abstract：:Hypoactive sexual desire disorder (HSDD) affects nearly 1 in 10 women. Thus, it is essential for pharmacists and other health care providers to be comfortable when discussing a patient's sexual health to ensure appropriate triage so that the specific causes of HSDD can be identified and potential recommendations provi...

journal_title：Pharmacotherapy

authors： Lodise NM

更新日期：2013-04-01 00:00:00

abstract：:A 39-year-old woman was evaluated for possible liver transplantation due to rapidly developing hepatic failure 4 weeks after initiation of oral minocycline 100 mg twice a day for the treatment of acne. The patient developed a maculopapular rash, malaise, fever, nausea, and vomiting 2 weeks prior to admission to the ho...

journal_title：Pharmacotherapy

authors： Min DI,Burke PA,Lewis WD,Jenkins RL

更新日期：1992-01-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the toxicity of amphotericin B deoxycholate formulations. DESIGN:In vitro experiment. SETTING:University research center. MATERIAL:Human mononuclear THP-1 cells. INTERVENTION:The human mononuclear cells were exposed in vitro for 2 hours to the following deoxycholate formulations of ampho...

journal_title：Pharmacotherapy

authors： Cleary JD,Rogers PD,Chapman SW

更新日期：2003-05-01 00:00:00

abstract：:We conducted a retrospective analysis to evaluate the relationship between anxiolytic or hypnotic therapy and maintenance of therapy with selective serotonin reuptake inhibitors (SSRIs). Subjects were 654 patients who received anxiolytics or hypnotics early in SSRI therapy (study group ) and 15,172 patients who did no...

journal_title：Pharmacotherapy

authors： Shields SA,Gregor KJ,Young CH,James SP

更新日期：1998-11-01 00:00:00

abstract：:The efficacy of the sodium-glucose cotransporter 2 (SGLT2) inhibitors canagliflozin, dapagliflozin, and empagliflozin in reducing hyperglycemia in patients with type 2 diabetes is well documented. In addition, positive effects have been observed with these agents on nonglycemic variables, such as reductions in body we...

journal_title：Pharmacotherapy

authors： Trujillo JM,Nuffer WA

更新日期：2017-04-01 00:00:00

abstract：:Starting lipid-lowering therapy in the hospital, especially with statins, has become an important component in the management of patients with acute coronary syndromes (ACS). It improves outcomes and increases patient motivation and long-term adherence. In addition, discontinuation of statin therapy in patients with A...

journal_title：Pharmacotherapy

authors： Paradiso-Hardy FL,Gordon WL,Jackevicius CA,Kertland HR,Pearson GJ,Pickering JL,Poirier L,Semchuk BM,Verret L

更新日期：2003-04-01 00:00:00