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Synthesis and biological properties of new 1beta-methylcarbapenems containing heteroaromatic thioether moiety.

Abstract：

:The synthesis and biological activities of a series of new 1beta-methylcarbapenems 1a-h having heteroaromatic thioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1,2,3-thiadiazole derivative 1h showed the most potent antibacterial activity and advanced pharmacokinetics in comparison with meropenem.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Shin KJ,Koo KD,Yoo KH,Kang YK,Park SW,Kim DJ

doi

10.1016/s0960-894x(01)00451-6

subject

Has Abstract

pub_date

2001-09-03 00:00:00

pages

2397-9

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960894X01004516

journal_volume

11

pub_type

杂志文章

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