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Aminofurazans as potent inhibitors of AKT kinase.

Abstract：

:AKT inhibitors containing an imidazopyridine aminofurazan scaffold have been optimized. We have previously disclosed identification of the AKT inhibitor GSK690693, which has been evaluated in clinical trials in cancer patients. Herein we describe recent efforts focusing on investigating a distinct region of this scaffold that have afforded compounds (30 and 32) with comparable activity profiles to that of GSK690693.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Rouse MB,Seefeld MA,Leber JD,McNulty KC,Sun L,Miller WH,Zhang S,Minthorn EA,Concha NO,Choudhry AE,Schaber MD,Heerding DA

doi

10.1016/j.bmcl.2009.01.002

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

1508-11

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)00007-9

journal_volume

19

pub_type

杂志文章

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