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Adamantyl N-benzylbenzamide: new series of depigmentation agents with tyrosinase inhibitory activity.

Abstract：

:A new series of polyhydroxylated N-benzylbenzamide derivatives containing an adamantyl moiety has been synthesized, and the depigmenting and tyrosinase inhibitory activities of the molecules were evaluated. The lipophilic character of the adamantyl moiety appeared to confer greater depigmentation power on the benzamide derivatives as compared to those lacking adamantyl substitution. Molecular modeling was applied in order to elucidate the interactions between ligands and tyrosinase that led to inhibition.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Baek HS,Hong YD,Lee CS,Rho HS,Shin SS,Park YH,Joo YH

doi

10.1016/j.bmcl.2011.12.144

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

2110-3

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00033-9

journal_volume

22

pub_type

杂志文章

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