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Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication.

Abstract：

:Triterpene derivatives were analyzed for anti-HIV-1 activity and for cellular toxicity. Betulinic aldehyde, betulinic nitrile, and morolic acid derivatives were identified to have anti-HIV-1 activity. These derivatives inhibit a late step in virus replication, likely virus maturation.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Dorr CR,Yemets S,Kolomitsyna O,Krasutsky P,Mansky LM

doi

10.1016/j.bmcl.2010.10.078

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

542-5

issue

1

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)01539-8

journal_volume

21

pub_type

杂志文章

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