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Antiproliferative activity of 2,3-disubstituted indoles toward apoptosis-resistant cancers cells.

Abstract：

:Many types of cancer, including glioma, melanoma, NSCLC, among others, are resistant to apoptosis induction and poorly responsive to current therapies with propaptotic agents. We describe a series of 2,3-disubstituted indoles, which display cytostatic rather than cytotoxic effects in cancer cells, and serve as a new chemical scaffold to develop anticancer agents capable of combating apoptosis-resistant cancers associated with dismal prognoses.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Magedov IV,Lefranc F,Frolova LV,Banuls LM,Peretti AS,Rogelj S,Mathieu V,Kiss R,Kornienko A

doi

10.1016/j.bmcl.2013.03.110

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

3277-82

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)00438-1

journal_volume

23

pub_type

杂志文章

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