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Redox-responsive and calcium-dependent switching of glycosyldisulfide interactions with Concanavalin A.

Abstract：

:Glycosyldisulfides can interact efficiently with carbohydrate-binding entities. This has been shown for a range of thiosaccharide dimers when tested for their effects against the lectin Concanavalin A using a modified quartz crystal microbalance-technique. Contrary to the thiosaccharide monomers, showing no significant binding up to 10 mM, several of the dimers showed IC(50)-values in the low millimolar range. Three of the glycosyldisulfides tested also displayed very high positive apparent cooperativity effects that were found to be both calcium-dependent and redox-responsive.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Pei Z,Aastrup T,Anderson H,Ramström O

doi

10.1016/j.bmcl.2005.04.024

subject

Has Abstract

pub_date

2005-06-02 00:00:00

pages

2707-10

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00485-3

journal_volume

15

pub_type

杂志文章

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