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Sulfenamides as prodrugs of NH-acidic compounds: a new prodrug option for the amide bond.

Abstract：

:The objective of this report is to introduce the novel concept of utilizing sulfenamides as prodrugs for compounds containing an NH-acidic functionality, particularly weakly acidic amide-type functionalities (amides, ureas, carbamates, etc.). Included are the syntheses and physicochemical characterizations of some model sulfenamides to illustrate the promise of this new prodrug technology.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Guarino VR,Karunaratne V,Stella VJ

doi

10.1016/j.bmcl.2007.06.037

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

4910-3

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00718-4

journal_volume

17

pub_type

杂志文章

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