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Diaminopropionic acid lipopeptides: characterization studies of polyplexes aimed at pDNA delivery.

Abstract：

:Here we report a novel class of peptides-d-diaminopropionic acids (Dap)-for gene delivery. These peptides have attractive properties for gene delivery, and the advantage that they can be easily manipulated in relation to their composition, abiding with tailored-design. We characterized the toxicological and biophysical properties of DNA particles resulting from the interaction of the nucleic acid with a series of Dap(8) peptides conjugated to different alkyl groups. These peptides formed small and homogenous DNA particle populations that protected against DNase I degradation at non-toxic concentrations. However, despite the similarity between these peptides and others that are arginine-rich, and efficient vectors, functional studies suggest the need for additional modifications in the carriers to improve their DNA delivery efficiency. Taken together, these studies underscore the relevance of the overall structure of the carrier and the complexity of designing from scratch a carrier.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Viola JR,Strömberg R,Simonson OE,Andaloussi SE,Smith CI,Murtola M

doi

10.1016/j.bmcl.2012.06.103

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

5635-8

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00863-3

journal_volume

22

pub_type

杂志文章

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