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Ganglioside GM1 mimics: lipophilic substituents improve affinity for cholera toxin.

Abstract：

:Ganglioside GM1 mimics including (R)-2-hydroxy-3-cyclohexylpropionic acid or (R)-2-hydroxy-3-phenylpropionic acid as replacements for NeuAc are stronger cholera toxin binders than the parent ligand 2, which includes (R)-2-hydroxy-propionic acid.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Arosio D,Baretti S,Cattaldo S,Potenza D,Bernardi A

doi

10.1016/j.bmcl.2003.07.007

subject

Has Abstract

pub_date

2003-11-03 00:00:00

pages

3831-4

issue

21

eissn

0960-894X

issn

1464-3405

pii

S0960894X03008291

journal_volume

13

pub_type

杂志文章

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