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4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na+/H+ exchanger isoform-1 (NHE-1) inhibitors.

Abstract：

:A series of 4-substituted (benzo[b]thiophene-2-carbonyl)guanidines was synthesized and evaluated for the NHE-1 inhibitory activity and cardioprotective efficacy both in vitro and in vivo. Several analogs exhibited a strong inhibition on NHE-1, and which was generally well correlated with their cardioprotective efficacy. Especially the 4-nitro 20 and cyano 50 compounds excellently improved the cardiac function and reduced infarct size against ischemia/reperfusion injury.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Lee S,Lee H,Yi KY,Lee BH,Yoo SE,Lee K,Cho NS

doi

10.1016/j.bmcl.2005.04.046

subject

Has Abstract

pub_date

2005-06-15 00:00:00

pages

2998-3001

issue

12

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00528-7

journal_volume

15

pub_type

杂志文章

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