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Studies on the interactions between some flavonols and cyclodextrins.

Abstract：

:The interactions of some natural flavonols with alpha, beta- and gamma-Cds have been investigated. Guest molecules were galangin, kaempferol and quercetin. Inclusion complexes were prepared by kneading and freeze-drying. The complexes were characterized using different physico-chemical methods based on differential scanning calorimetry (DSC), infrared spectroscopy (IR) and NMR spectroscopy. In the proton and carbon spectra the effects of complexation on the chemical shifts of the internal and external protons of Cds in the presence of each flavonoid were observed. Moreover, the water-solubility of the flavonols in the presence of Cds was also evaluated. The increased solubility of quercetin and kaempferol in the presence of beta-Cd was evidenced. For all three guests, multidimensional NMR experiments in DMSO and water are consistent with dynamic binding processes, dominated by insertion of the B ring into the wider rim of the Cd cavity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Bergonzi MC,Bilia AR,Di Bari L,Mazzi G,Vincieri FF

doi

10.1016/j.bmcl.2007.08.067

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

5744-8

issue

21

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)01024-4

journal_volume

17

pub_type

杂志文章

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