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Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators.

Abstract：

:We herein report the discovery of four series of fused 5,6-bicyclic heterocycles as γ-secretase modulators. Synthesis and SAR of these series are discussed. These compounds represent a new class of γ-secretase modulators that demonstrate moderate to good in vitro potency in inhibiting Aβ(42) production.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Qin J,Dhondi P,Huang X,Mandal M,Zhao Z,Pissarnitski D,Zhou W,Aslanian R,Zhu Z,Greenlee W,Clader J,Zhang L,Cohen-Williams M,Jones N,Hyde L,Palani A

doi

10.1016/j.bmcl.2010.12.012

subject

Has Abstract

pub_date

2011-01-15 00:00:00

pages

664-9

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)01766-X

journal_volume

21

pub_type

杂志文章

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