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New fluorogenic substrate for the first continuous steroid sulfatase assay.

Abstract：

:The screening for new inhibitors of steroid sulfatase requires an efficient test system. To overcome the shortcomings of the available discontinuous fluorimetric assay, several coumarin-type compounds were investigated as potential new substrates. 3,4-Benzocoumarin 7-O-sulfate was found to have appropriate substrate properties for the establishment of the first direct continuous assay of steroid sulfatase.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Bilban M,Billich A,Auer M,Nussbaumer P

doi

10.1016/s0960-894x(00)00144-x

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

967-9

issue

9

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(00)00144-X

journal_volume

10

pub_type

杂志文章

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