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Molecular recognition of a DNA:RNA hybrid: sub-nanomolar binding by a neomycin-methidium conjugate.

Abstract：

:A novel neomycin-methidium conjugate was synthesized. The covalent linkage of the aminoglycoside to an intercalator, a derivative of ethidium bromide, results in a new conjugate capable of selective recognition of the DNA:RNA hybrid duplex. Spectroscopic methods: UV, CD, fluorescence, and calorimetric techniques: DSC and ITC were used to characterize the sub-nanomolar binding displayed by the conjugate for the DNA:RNA hybrid duplex, poly(dA):poly(rU).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Shaw NN,Xi H,Arya DP

doi

10.1016/j.bmcl.2008.05.090

subject

Has Abstract

pub_date

2008-07-15 00:00:00

pages

4142-5

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)00597-0

journal_volume

18

pub_type

杂志文章

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