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Synthesis of a novel ester analog of nucleic acids bearing a serine backbone.

Abstract：

:A novel analog of nucleic acids bearing an optically active serine ester backbone, serine-based nucleobase-linked polyester (SNE), was synthesized. Monomers containing a thymine base were synthesized from L- and D-serines. Furthermore, reaction conditions were thoroughly examined for the ester bond formation by using a new phosphonium-type condensing reagent on a solid support without racemization. The release of the dimer from the resin was also investigated using a new type of linker, which could be cleaved under neutral conditions.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Murata A,Wada T

doi

10.1016/j.bmcl.2006.02.076

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

2933-6

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00272-1

journal_volume

16

pub_type

杂志文章

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