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Oxidative calcium release from catechol.

Abstract：

:Oxidation of 4-methylcatechol previously exposed to aqueous calcium chloride was shown by ion chromatography to be associated with release of calcium ions. The catechol was oxidised to the corresponding orthoquinone by the use of tyrosinase from Agaricus bisporus. The oxidative release of calcium from the catechol is ascribed to the diminution of the available hydroxyl functions able to act as chelating groups. Our results suggest that the redox status of melanin may regulate calcium binding and influence calcium levels in pigmented cells.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Riley PA,Stratford MR

doi

10.1016/j.bmcl.2015.02.036

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

1453-4

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)00143-2

journal_volume

25

pub_type

杂志文章

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