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N-substituted-3-arylpyrrolidines: potent and selective ligands at serotonin 1A receptor.

Abstract：

:3-Arylpyrrolidines are synthesized through the coupling of N-benzyl-3-(methanesulfonyloxy)pyrrolidine with diarylcuprates. Pharmacological evaluation of a series of N-substituted-3-arylpyrrolidines toward several neurotransmitter receptors indicated that some of them are good ligands for serotonin 1A receptor. Particularly, N-[(N-saccharino)butyl]pyrrolidines were found to be potent and selective ligands. A preliminary biological evaluation for several selected compounds indicated that they are potentially effective antianxiety and antidepressant agents.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ahn KH,Lee SJ,Lee CH,Hong CY,Park TK

doi

10.1016/s0960-894x(99)00201-2

subject

Has Abstract

pub_date

1999-05-17 00:00:00

pages

1379-84

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960894X99002012

journal_volume

9

pub_type

杂志文章

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