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Nitrobenzene compounds inhibit expression of VCAM-1.

Abstract：

:A series of nitrobenzene compounds has been discovered as potent inhibitors of VCAM-1 expression and, therefore, potential drug candidates for autoimmune and allergic inflammatory diseases. Structure-activity relationship (SAR) studies showed that a nitro group and two other electron-withdrawing groups are essential for these compounds to be potent inhibitors of VCAM-1 expression.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Meng CQ,Zheng XS,Holt LA,Hoong LK,Somers PK,Hill RR,Saxena U

doi

10.1016/s0960-894x(01)00306-7

subject

Has Abstract

pub_date

2001-07-23 00:00:00

pages

1823-7

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960894X01003067

journal_volume

11

pub_type

杂志文章

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