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Aminoalkoxybenzyl pyrrolidines as novel human urotensin-II receptor antagonists.

Abstract：

:High throughput screening of the corporate compound collection led to the discovery of a novel series of substituted aminoalkoxybenzyl pyrrolidines as human urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, and optimization of the initial hit that led to the identification of a truncated sub-series, represented by SB-436811 (1a), are described.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Jin J,Dhanak D,Knight SD,Widdowson K,Aiyar N,Naselsky D,Sarau HM,Foley JJ,Schmidt DB,Bennett CD,Wang B,Warren GL,Moore ML,Keenan RM,Rivero RA,Douglas SA

doi

10.1016/j.bmcl.2005.04.074

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

3229-32

issue

13

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00569-X

journal_volume

15

pub_type

杂志文章

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