(1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production.

Abstract:

:Synthesis, pharmacology, and pharmacokinetic profiles of (1R, 2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile are reported. This compound demonstrated remarkable potency for stimulating hair growth in a male C3H mouse model as well as reducing sebum production in the male Syrian hamster ear model.

journal_name

Bioorg Med Chem Lett

authors

Hu LY,Du D,Hoffman J,Smith Y,Fedij V,Kostlan C,Johnson TR,Huang Y,Kesten S,Harter W,Yue WS,Li JJ,Barvian N,Mitchell L,Lei HJ,Lefker B,Carroll M,Dettling D,Krieger-Burke T,Samas B,Yalamanchili R,Lapham K,Pocaly

doi

10.1016/j.bmcl.2007.07.075

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

5983-8

issue

21

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00869-4

journal_volume

17

pub_type

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