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Opsin shift in an aldolase antibody.

Abstract：

:An antibody-retinal assembly that mimics the opsin shift (OS) of the naturally occurring visual pigments is reported. Both experiments and calculations show that the aldolase antibody 33F12 covalently binds all-trans retinal via a protonated Schiff base with a lysine residue. This chromophore, which exhibits a remarkable opsin red shift (140 nm), represents a useful model system for studying the factors that contribute to the OS.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Grynszpan F,Keinan E

doi

10.1016/s0960-894x(99)00406-0

subject

Has Abstract

pub_date

1999-08-16 00:00:00

pages

2419-24

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(99)00406-0

journal_volume

9

pub_type

杂志文章

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