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Identification of nonplanar small molecule for G-quadruplex grooves: molecular docking and molecular dynamic study.

Abstract：

:DNA G-quadruplex is an attractive drug target for anticancer therapy. Most G-quadruplex ligands have little selectivity, due to π-stacking interaction with common G-tetrads surface. Thanks to the varieties of G-quadruplex grooves, the groove-binding ligand is expected to create high selectivity. Therefore, developing novel molecular geometries that target G-quadruplex groove has been paid growing attention. In this work, steroid FG, a special nonplanar and nonaromatic small molecule, interacting with different conformations of G-quadruplexes has been studied by molecular docking and molecular dynamics simulations. The results showed the selectivity of the hydrophobic group of steroid FG for the wide groove of antiparallel G-quadruplex. The methyl groups on the tetracyclic ring of steroid represent the specific binding ability for the small hydrophobic cavity formed by reversed stacking of G-tetrads in antiparallel G-quadruplex groove. This work provides new insight for developing new classes of G-quadruplex groove-binding ligands.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Li J,Jin X,Hu L,Wang J,Su Z

doi

10.1016/j.bmcl.2011.09.125

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

6969-72

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)01380-1

journal_volume

21

pub_type

杂志文章

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