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Targeting TRAIL.

Abstract：

:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), also known as Apo2L, has been investigated in the past decade for its promising anticancer activity due to its ability to selectively induce apoptosis in tumoral cells by binding to TRAIL receptors (TRAIL-R). Macromolecules such as agonistic monoclonal antibodies and recombinant TRAIL have not proven efficacious in clinical studies, therefore several small molecules acting as TRAIL-R agonists are emerging in the scientific literature. In this work we focus on systemizing these drug molecules described in the past years, in order to better understand and predict the requirements for a novel anti-tumoral therapy based on the TRAIL-R-induced apoptotic mechanism.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ion GND,Nitulescu GM,Popescu CI

doi

10.1016/j.bmcl.2019.07.053

subject

Has Abstract

pub_date

2019-09-15 00:00:00

pages

2527-2534

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(19)30522-0

journal_volume

29

pub_type

杂志文章,评审

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