NEW BASE-ALTERED ADENOSINE ANALOGUES: SYNTHESIS AND AFFINITY AT ADENOSINE A1 and A2A RECEPTORS.

Abstract:

:N6-Substituted adenosine analogues containing cyclic hydrazines or chiral hydroxy (ar)alkyl groups, designed to interact with the S2 and S3 receptor subregions, have been synthesized and their binding to the adenosine A1 and A2A receptors have been investigated. Examples of both types of compounds were found to exhibit highly selective binding (Ki in low nM range) to the rat A1 receptor.

journal_name

Bioorg Med Chem Lett

authors

Ha SB,Melman N,Jacobson KA,Nair V

doi

10.1016/S0960-894X(97)10177-9

subject

Has Abstract

pub_date

1997-12-16 00:00:00

pages

3085-3090

issue

24

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(97)10177-9

journal_volume

7

pub_type

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