Abstract:
:N6-Substituted adenosine analogues containing cyclic hydrazines or chiral hydroxy (ar)alkyl groups, designed to interact with the S2 and S3 receptor subregions, have been synthesized and their binding to the adenosine A1 and A2A receptors have been investigated. Examples of both types of compounds were found to exhibit highly selective binding (Ki in low nM range) to the rat A1 receptor.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Ha SB,Melman N,Jacobson KA,Nair Vdoi
10.1016/S0960-894X(97)10177-9subject
Has Abstractpub_date
1997-12-16 00:00:00pages
3085-3090issue
24eissn
0960-894Xissn
1464-3405pii
S0960-894X(97)10177-9journal_volume
7pub_type
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