Novel endoperoxides: synthesis and activity against Candida species.

Abstract:

:Fifteen new endoperoxides have been synthesised and tested for activity against pathogenic Candida species. These endoperoxides can be prepared in high yields, in one to three steps, from inexpensive starting materials. Despite chemical and structural similarities, their inhibitory activity against Candida growth varied greatly from one endoperoxide to another, and one species to another. This study of susceptibility to endoperoxide compounds presented here may lead to the development of potent new antifungal agents.

journal_name

Bioorg Med Chem Lett

authors

Macreadie P,Avery T,Greatrex B,Taylor D,Macreadie I

doi

10.1016/j.bmcl.2005.10.101

subject

Has Abstract

pub_date

2006-02-15 00:00:00

pages

920-2

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)01402-2

journal_volume

16

pub_type

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