Abstract:
:Fifteen new endoperoxides have been synthesised and tested for activity against pathogenic Candida species. These endoperoxides can be prepared in high yields, in one to three steps, from inexpensive starting materials. Despite chemical and structural similarities, their inhibitory activity against Candida growth varied greatly from one endoperoxide to another, and one species to another. This study of susceptibility to endoperoxide compounds presented here may lead to the development of potent new antifungal agents.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Macreadie P,Avery T,Greatrex B,Taylor D,Macreadie Idoi
10.1016/j.bmcl.2005.10.101subject
Has Abstractpub_date
2006-02-15 00:00:00pages
920-2issue
4eissn
0960-894Xissn
1464-3405pii
S0960-894X(05)01402-2journal_volume
16pub_type
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