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Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA beta-lactams.

Abstract：

:Novel C(3) propenylamide and propenylsulfonamide cephalosporins have been synthesized and tested for their ability to inhibit the penicillin-binding protein 2' (PBP2') from Staphylococcus epidermidis and the growth of a panel of clinically relevant bacterial species, including methicillin-resistant Staphylococcus aureus (MRSA). The most potent compounds inhibited the growth of MRSA strains with minimum inhibitory concentrations (MIC) as low as 1 microg/mL. The structure-activity relationship revealed the potential for further optimization of this new cephalosporin class.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Pohlmann J,Vasilevich NI,Glushkov AI,Kellenberger L,Shapiro S,Caspers P,Page MG,Danel F

doi

10.1016/j.bmcl.2010.05.110

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

4635-8

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)00771-7

journal_volume

20

pub_type

杂志文章

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