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The food-grade antimicrobial xanthorrhizol targets the enoyl-ACP reductase (FabI) in Escherichia coli.

Abstract：

:Xanthorrhizol, isolated from the Indonesian Java turmeric Curcuma xanthorrhiza, displays broad-spectrum antibacterial activity. We report herein the evidence that mechanism of action of xanthorrhizol may involve FabI, an enoyl-(ACP) reductase, inhibition. The predicted Y156V substitution in the FabI enzyme promoted xanthorrhizol resistance, while the G93V mutation originally known for triclosan resistance was not effective against xanthorrhizol. Two other mutations, F203L and F203V, conferred FabI enzyme resistance to both xanthorrhizol and triclosan. These results showed that xanthorrhizol is a food-grade antimicrobial compound targeting FabI but with a different mode of binding from triclosan.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Yogiara,Mordukhova EA,Kim D,Kim WG,Hwang JK,Pan JG

doi

10.1016/j.bmcl.2020.127651

subject

Has Abstract

pub_date

2020-12-15 00:00:00

pages

127651

issue

24

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(20)30762-9

journal_volume

30

pub_type

杂志文章

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