Abstract:
:The oxidation reactions of 5-aminopyrimidine derivatives in dimethyl sulphoxide (DMSO) were studied. The DMSO solutions of the studied compounds became deeply coloured within a few hours or days. The oxidation products can undergo further condensation reactions with the starting pyrimidines to yield bipyrimidines and/or pyrimidopteridines. The reaction mechanism of the oxidation-condensation reaction was also supported by reactions of the 5-aminopyrimidines with alloxan (2,4,5,6-tetraoxopyrimidine). DMSO is often used as the solvent in in vitro tests of biological activities, but it is also an oxidising agent and may react with solute molecules and significantly affect the quality of the generated biochemical data.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Procházková E,Jansa P,Březinová A,Cechová L,Mertlíková-Kaiserová H,Holý A,Dračínský Mdoi
10.1016/j.bmcl.2012.08.065subject
Has Abstractpub_date
2012-10-15 00:00:00pages
6405-9issue
20eissn
0960-894Xissn
1464-3405pii
S0960-894X(12)01076-1journal_volume
22pub_type
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