Abstract:
:Heterocyclic substituted derivatives of the antipsoriatic anthralin were synthesized and evaluated in vitro for their antiproliferative action against keratinocytes and their ability to induce keratinocyte differentiation. The indole-2-carboxylic acid analogue 2e exhibited the same excellent antiproliferative activity as anthralin and also induced terminal differentiation of keratinocytes. As a benefit of its strongly diminished potential to generate oxygen radicals, 2e did not induce damage of keratinocyte membranes.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Müller K,Reindl H,Breu Kdoi
10.1016/s0960-894x(00)00599-0subject
Has Abstractpub_date
2001-01-08 00:00:00pages
47-50issue
1eissn
0960-894Xissn
1464-3405pii
S0960-894X(00)00599-0journal_volume
11pub_type
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