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Peptoids as endothelin receptor antagonists.

Abstract：

:A series of new peptoids as endothelin receptor antagonists has been synthesized. Screening them for their ability to bind with endothelin receptors (ET(A) and ET(B)) competitively in the presence of (125I) endothelin led to the discovery of compounds as possible leads with IC50s in the low micromolar concentrations.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Dasgupta F,Gangadhar N,Bruhaspathy M,Verma AK,Sarin S,Mukherjee AK

doi

10.1016/s0960-894x(01)00009-9

subject

Has Abstract

pub_date

2001-02-26 00:00:00

pages

555-7

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960894X01000099

journal_volume

11

pub_type

杂志文章

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