Abstract:
:The underlying mechanisms of urocanic acid (UA) to induce immune suppression remain elusive until the recent finding that cis-UA acts via the serotonin, 5-hydroxytryptamine (5-HT) receptor subtype 5-HT(2A). In the present study, the interactions of cis-UA to 5-HT(2A) receptor were explored and compared with those of 5-HT to the same receptor using computational docking. Similar binding modes were observed for cis-UA and 5-HT with 5-HT(2A) receptor and the former possessed relatively higher binding affinity, which may account for cis-UA being a serotonin receptor agonist. Moreover, the molecular basis for the distinct binding affinities between the trans- and cis-UA with 5-HT(2A) receptor was also provided.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Shen L,Ji HFdoi
10.1016/j.bmcl.2009.07.143subject
Has Abstractpub_date
2009-09-15 00:00:00pages
5307-9issue
18eissn
0960-894Xissn
1464-3405pii
S0960-894X(09)01113-5journal_volume
19pub_type
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