d(TGGGAG) with 5'-nucleobase-attached large hydrophobic groups as potent inhibitors for HIV-1 envelop proteins mediated cell-cell fusion.

Abstract:

:The Hotoda's sequence substituted with TBDPS via 5'-end nucleobase existed as parallel quadruplex structure and exhibited inhibitory activities in an HIV-1 envelop proteins mediated cell-cell fusion assay. This result demonstrated that the 5'-aromatic groups of the Hotoda's sequence are allowed to have a large spatial freedom and remain to be optimized for its role in the binding to HIV-1 envelop proteins.

journal_name

Bioorg Med Chem Lett

authors

Chen W,Xu L,Cai L,Zheng B,Wang K,He J,Liu K

doi

10.1016/j.bmcl.2011.08.007

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

5762-4

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)01078-X

journal_volume

21

pub_type

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