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Synthesis and structure-activity relationships of PI3K/mTOR dual inhibitors from a series of 2-amino-4-methylpyrido[2,3-d]pyrimidine derivatives.

Abstract：

:Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway by PI3K/mTOR dual inhibitors provides a promising new approach to the treatment of cancers. In this Letter, we identified structurally novel and potent PI3K/mTOR dual inhibitors from a series of 2-amino-4-methylpyrido[2,3-d]pyrimidine derivatives. Their synthesis and structure-activity relationships are reported.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Han F,Lin S,Liu P,Tao J,Yi C,Xu H

doi

10.1016/j.bmcl.2014.07.073

subject

Has Abstract

pub_date

2014-09-15 00:00:00

pages

4538-4541

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)00808-7

journal_volume

24

pub_type

杂志文章

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