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Synthesis of novel quinoxaline derivatives and its cytotoxic activities.

Abstract：

:Substituted dihydroquinozalin-2-ones (1-16) have been synthesized easily by the use of copper-catalyzed coupling method. The reactions of 2-haloanilines with a variety of alpha-amino acids in the presence of copper (I) iodide gave corresponding 3-substituted dihydroquinozalin-2-ones in up to 86% yield. Some new quinoxalin-2-ones (2, 4, 5, 13 and 16) have moderate cytotoxic activity toward HeLaS3 cell lines at 4.9-18.1microM.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Tanimori S,Nishimura T,Kirihata M

doi

10.1016/j.bmcl.2009.06.007

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

4119-21

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)00827-0

journal_volume

19

pub_type

杂志文章

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