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A novel series of potent and selective IKK2 inhibitors.

Abstract：

:A novel series of aminopyrimidine IKK2 inhibitors have been developed which show excellent in vitro inhibition of this enzyme and good selectivity over the IKK1 isoform. The relative potency and selectivity of these compounds has been rationalized using QSAR and structure-based modelling.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Bingham AH,Davenport RJ,Gowers L,Knight RL,Lowe C,Owen DA,Parry DM,Pitt WR

doi

10.1016/j.bmcl.2003.10.047

subject

Has Abstract

pub_date

2004-01-19 00:00:00

pages

409-12

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960894X03011491

journal_volume

14

pub_type

杂志文章

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