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Synthesis and evaluation of a novel series of indoloisoquinolines as small molecule anti-malarial leads.

Abstract：

:A group of novel synthetic indoloisoquinolines was prepared and its potential as a novel series of small-molecule anti-malarial leads was assessed. The structure-activity relationship on variation of three distinct regions of chemical space was investigated. A lead compound was generated with an activity close to that observed for a known anti-malarial natural product, dihydrousambarensine, that shares the indoloisoquinoline template structure.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Horrocks P,Fallon S,Denman L,Devine O,Duffy LJ,Harper A,Meredith EL,Hasenkamp S,Sidaway A,Monnery D,Phillips TR,Allin SM

doi

10.1016/j.bmcl.2011.12.071

subject

Has Abstract

pub_date

2012-02-15 00:00:00

pages

1770-3

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)01752-5

journal_volume

22

pub_type

杂志文章

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