Synthesis and DNA binding ability of cyclam-amino acid conjugates.

Abstract:

:N-Substituted cyclam-amino acid conjugates have been synthesised both in solution and on the solid phase. The DNA binding affinity of these species has been studied: the nature of the amino acid strongly influences the change in melting temperature suggesting that simple cyclam-peptide conjugates could interact with DNA in a highly selective manner.

journal_name

Bioorg Med Chem Lett

authors

Venkata Ramana A,Watkinson M,Todd MH

doi

10.1016/j.bmcl.2008.03.045

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

3007-10

issue

9

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)00318-1

journal_volume

18

pub_type

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