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New potential inhibitors of DNA topoisomerase. Part II: Design and synthesis of alpha-lapachone derivatives under microwave irradiation.

Abstract：

:A new series of potential inhibitors of DNA topoisomerase II were synthesized from facile materials (aromatic aldehydes, Meldrum's acid and 2-hydroxynaphthalene-1,4-dione) under microwave irradiation. The method provides a valuable tool in designing new and more potent cytotoxic analogues. This procedure is advantageous both economically and environmentally.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Wei P,Zhang X,Tu S,Yan S,Ying H,Ouyang P

doi

10.1016/j.bmcl.2008.12.006

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

828-30

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)01509-6

journal_volume

19

pub_type

杂志文章

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