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Leptostatin: a synthetic hybrid of the cytotoxic polyketides callystatin A and leptomycin B.

Abstract：

:Four stereoisomeric hybrids of the polyketide natural products callystatin A and leptomycin B have been prepared by parallel synthetic routes involving chiral allenylstannane methodology. Like their natural counterparts, these hybrids exhibit nanomolar levels of cytotoxicity toward HCT-116 human colon cancer cells.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Marshall JA,Mikowski AM,Bourbeau MP,Schaaf GM,Valeriote F

doi

10.1016/j.bmcl.2005.09.084

subject

Has Abstract

pub_date

2006-01-15 00:00:00

pages

320-3

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)01264-3

journal_volume

16

pub_type

杂志文章

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